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نائل محمود أبوطه

Associate Professor

عضو هيئة تدريس

كلية العلوم
كلية العلوم-كرسي أبحاث المنتجات الحيوية رقم المعمل AB85
المنشورات
مقال فى مجلة
2015

Antiproliferative and antibacterial metabolites from endophytes isolated from Calotropis procera and Phoenix dactylifera

Endophytes associated with Calotropis procera and Phoenix dactylifera were screened for their capacity to produce bioactive metabolites against a panel of cancer cell lines and human pathogens. In the present study, the antiproliferative activity of ethyl acetate extract of MN05 displayed concentration-dependent inhibitory effects against the HepG2 and Jurkat cell lines, with an IC50 of 69.13 and 85.56μg/ml respectively. The extract induced morphological abnormalities in the cells and inhibited cells migration. Antimicrobial activity was found against both Gram positive and Gram negative microorganisms. No antifungal activity was detected against candida sp. MN05 extract showed very strong antibacterial effect against Mycobacterium sp. producing halos with an average diameter of 30.00±.0000 mm followed by Bacillus cereus (23.0±00 mm), Bacillus subtilis (20.05±0.21) and Proteus vulgaris (19.50±0.07). MN05 extract enhanced IL-8 and IL6 secretions in HepG2 cells. Further investigation to identify the active compound/s and mode of action is required.

رقم الانشاء
10 (10)
مجلة/صحيفة
Research Journal of Biotechnology
الصفحات
47-55
مزيد من المنشورات
publications

Cancer is reported to be the leading cause of death and illness worldwide. This research aims to evaluate the phytochemicals,

بواسطة Ahmed I. Alsayadi1 · Nael Abutaha1 · Bader O. Almutairi1 · Fahd A. Al‑Mekhlaf1 · Mohamed A. Wadaan1
2022
تم النشر فى:
Environmental Science and Pollution Research
publications

The essential oil of Ducrosia ismaelis Asch. (Apiaceae) that grows wild in Saudi Arabia was investigated utilizing gas chromatography (GC), and gas chromatography-mass spectrometry. Fifty…

بواسطة Ramzi A. Mothana, Fahd A. Nasr, Jamal M. Khaled, Omar M. Noman, Nael Abutaha, Adnan J. Al-Rehaily, Omar M. Almarfadi and Mine Kurkcuoglu
تم النشر فى:
open chemistry
publications

Plants of the Lavandula genus have been widely used in folk and traditional medicine. The aim of this study was to evaluate the qualitative and quantitative chemical composition of the essential…

بواسطة Mohamed HabibOueslatiabNaelAbutahacFarajAl-GhamdidImededdineArbi NehdieFahd A.NasrcLamjedMansourcMohammedAL-ZharanifAbdel HalimHarrath
تم النشر فى:
Journal of King Saud University – Science