Antiproliferative and antibacterial metabolites from endophytes isolated from Calotropis procera and Phoenix dactylifera
Endophytes associated with Calotropis procera and Phoenix dactylifera were screened for their capacity to produce bioactive metabolites against a panel of cancer cell lines and human pathogens. In the present study, the antiproliferative activity of ethyl acetate extract of MN05 displayed concentration-dependent inhibitory effects against the HepG2 and Jurkat cell lines, with an IC50 of 69.13 and 85.56μg/ml respectively. The extract induced morphological abnormalities in the cells and inhibited cells migration. Antimicrobial activity was found against both Gram positive and Gram negative microorganisms. No antifungal activity was detected against candida sp. MN05 extract showed very strong antibacterial effect against Mycobacterium sp. producing halos with an average diameter of 30.00±.0000 mm followed by Bacillus cereus (23.0±00 mm), Bacillus subtilis (20.05±0.21) and Proteus vulgaris (19.50±0.07). MN05 extract enhanced IL-8 and IL6 secretions in HepG2 cells. Further investigation to identify the active compound/s and mode of action is required.
Cancer is reported to be the leading cause of death and illness worldwide. This research aims to evaluate the phytochemicals,
The essential oil of Ducrosia ismaelis Asch. (Apiaceae) that grows wild in Saudi Arabia was investigated utilizing gas chromatography (GC), and gas chromatography-mass spectrometry. Fifty…
Plants of the Lavandula genus have been widely used in folk and traditional medicine. The aim of this study was to evaluate the qualitative and quantitative chemical composition of the essential…