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نائل محمود أبوطه

Associate Professor

عضو هيئة تدريس

كلية العلوم
كلية العلوم-كرسي أبحاث المنتجات الحيوية رقم المعمل AB85
المنشورات
مقال فى مجلة
2015

Synthesis of novel series of N'-(2-Oxoindolin-3-ylidene)-2-propylpentane hydrazide-hydrazone derivatives and screening in zebrafish embryos. Molecules, 20(8), 14638-14655

Eight novel N′-(2-oxoindolin-3-ylidene)-2-propylpentane hydrazide-hydrazone derivatives 4a–h were synthesized and fully characterized by IR, NMR (1H-NMR and 13C-NMR), elemental analysis, and X-ray crystallography. The cyto-toxicity and in vitro anti-cancer evaluation of the prepared compounds have been assessed against two different human tumour cell lines including human liver (HepG2) and leukaemia (Jurkat), as well as in normal cell lines derived from human embryonic kidney (HEK293) using MTT assay. The compounds 3e, 3f, 4a, 4c, and 4e revealed promising anti-cancer activities in tested human tumour cells lines (IC50 values between 3 and 7 μM) as compared to the known anti-cancer drug 5-Fluorouracil (IC50 32–50 μM). Among the tested compounds, 4a showed specificity against leukaemia (Jurkat) cells, with an IC50 value of 3.14 μM, but this compound was inactive in liver cancer and normal cell lines.

نوع عمل المنشور
بحث
اسم الناشر
molecules
مزيد من المنشورات
publications

Cancer is reported to be the leading cause of death and illness worldwide. This research aims to evaluate the phytochemicals,

بواسطة Ahmed I. Alsayadi1 · Nael Abutaha1 · Bader O. Almutairi1 · Fahd A. Al‑Mekhlaf1 · Mohamed A. Wadaan1
2022
تم النشر فى:
Environmental Science and Pollution Research
publications

The essential oil of Ducrosia ismaelis Asch. (Apiaceae) that grows wild in Saudi Arabia was investigated utilizing gas chromatography (GC), and gas chromatography-mass spectrometry. Fifty…

بواسطة Ramzi A. Mothana, Fahd A. Nasr, Jamal M. Khaled, Omar M. Noman, Nael Abutaha, Adnan J. Al-Rehaily, Omar M. Almarfadi and Mine Kurkcuoglu
تم النشر فى:
open chemistry
publications

Plants of the Lavandula genus have been widely used in folk and traditional medicine. The aim of this study was to evaluate the qualitative and quantitative chemical composition of the essential…

بواسطة Mohamed HabibOueslatiabNaelAbutahacFarajAl-GhamdidImededdineArbi NehdieFahd A.NasrcLamjedMansourcMohammedAL-ZharanifAbdel HalimHarrath
تم النشر فى:
Journal of King Saud University – Science