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نائل محمود أبوطه

Associate Professor

عضو هيئة تدريس

كلية العلوم
كلية العلوم-كرسي أبحاث المنتجات الحيوية رقم المعمل AB85
المنشورات
مقال فى مجلة
2014

Evaluation of the Safe Use of the Larvicidal Fraction of Capparis Cartilaginea against Aedes caspius larvae . African Entomology 22(4): 838–846.

Larvicidal activity and cytotoxicity of fruit and leaf extracts of the Capparis cartilaginea were evaluated. No previous studies have been reported on the larvicidal activities of crude and column chromatographic fractions of fruit and leaf extracts of Capparis cartilaginea. In this study, HPLC analysis of the alkaloidal active fraction F2 of methanolic fruit extract showed the presence of a major peak. Crude aqueous fruit extract of C. cartilaginea was less toxic against Aedes caspius (LC50 = 172.02) compared to its column chromatographic fraction F2 (LC50 = 29.17). Cytotoxicity studies on HepG2 and MCF7 at 24 h post-treatment recorded survival rates ranging from 90 to 110%, respectively. Light and fluorescent microscopy revealed no effect on cell morphology at 100 µg/ml. The plasma membrane remained well defined and the nuclei were normal and exhibited diffused staining of the chromatin. Most active component(s) responsible for toxic activity against Aedes caspius was present in the fraction F2 of C. cartilaginea, which showed larvicidal efficacy in a dose-dependent manner. As a result, fraction F2 is a good candidate as an alternative natural larvicidal agent with no hepatotoxicity and at a low cost. Further investigation is required to identify and characterize active compounds.

نوع عمل المنشور
بحث
اسم الناشر
African Entomology
مزيد من المنشورات
publications

Cancer is reported to be the leading cause of death and illness worldwide. This research aims to evaluate the phytochemicals,

بواسطة Ahmed I. Alsayadi1 · Nael Abutaha1 · Bader O. Almutairi1 · Fahd A. Al‑Mekhlaf1 · Mohamed A. Wadaan1
2022
تم النشر فى:
Environmental Science and Pollution Research
publications

The essential oil of Ducrosia ismaelis Asch. (Apiaceae) that grows wild in Saudi Arabia was investigated utilizing gas chromatography (GC), and gas chromatography-mass spectrometry. Fifty…

بواسطة Ramzi A. Mothana, Fahd A. Nasr, Jamal M. Khaled, Omar M. Noman, Nael Abutaha, Adnan J. Al-Rehaily, Omar M. Almarfadi and Mine Kurkcuoglu
تم النشر فى:
open chemistry
publications

Plants of the Lavandula genus have been widely used in folk and traditional medicine. The aim of this study was to evaluate the qualitative and quantitative chemical composition of the essential…

بواسطة Mohamed HabibOueslatiabNaelAbutahacFarajAl-GhamdidImededdineArbi NehdieFahd A.NasrcLamjedMansourcMohammedAL-ZharanifAbdel HalimHarrath
تم النشر فى:
Journal of King Saud University – Science