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نوره عبدالله محمد البكيري

Assistant Professor

عضو هيئة تدريس

كلية الصيدلة
المبنى 8 الدور 2 رقم المكتب 47
المنشورات
مقال فى مجلة
2015

Transport of digoxin-loaded polymeric nanoparticles across BeWo cells, an in vitro model of human placental trophoblast

Albekairi, Norah A . 2015

Background: Fetal arrhythmias can lead to fetal congestive heart failure and hydrops fetalis. Digoxin (the first-line treatment) has low transplacental permeability and high risk of maternal side effects. Biodegradable digoxin-loaded PEGylated poly(lactic-co-glycolic acid) nanoparticles may increase digoxin transport across BeWo b30 cell monolayers (an in vitro model of trophoblast in human placenta) by reducing the drug's interaction with P-gp. Results/methodology: The nanoparticles showed high encapsulation efficiency and sustained release over 48 h. Transport studies revealed significantly increased permeability across BeWo cell layers of digoxin-loaded nanoparticles when compared with free digoxin. P-gp inhibition also increased the permeability of digoxin, but not digoxin-loaded nanoparticles. Conclusion: This represents a novel treatment strategy for fetal cardiovascular disease which may improve maternal and fetal outcomes.

رقم المجلد
DOI: 10.4155/tde.15.79
مجلة/صحيفة
Therapeutic delivery
الصفحات
1325-1334
مزيد من المنشورات
publications

The placenta serves as the interface between the maternal and fetal circulations and regulates the transfer of oxygen, nutrients, and waste products.

بواسطة Sanaalarab Al-Enazy ⁎, Shariq Ali ⁎, Norah Albekairi⁎, Marwa El-Tawil ⁎, Erik Rytting⁎
2016
publications

This chapter provides an overview of cell culture models that may be used to predict drug transport across relevant biological barriers.

بواسطة IRINA KALASHNIKOVA, NORAH ALBEKAIRI, SHARIQ ALI, SANAALARAB AL ENAZY, ERIK RYTTING
2016
تم النشر فى:
John Wiley & Sons, Inc
publications

Background: Fetal arrhythmias can lead to fetal congestive heart failure and hydrops fetalis. Digoxin (the first-line treatment) has low transplacental permeability and high risk of maternal side…

بواسطة Norah A Albekairi, Sanaalarab Al-Enazy, Shariq Ali , Erik Rytting
2015