DIRECTED LITHIATION AND SUBSTITUTION OF PYRIDINE DERIVATIVES

Journal Article

El-Hiti, Gamal A. . 2015

• نوع عمل المنشور: Review
• رابط المنشور على الويب: http://dx.doi.org/10.3987/REV-14-816
• المجلة \ الصحيفة: Heterocycles
• رقم العدد: 3
• رقم الإصدار السنوي: 91
• الصفحات: 479-504

مستخلص المنشور

 Directed lithiation of substituted pyridines containing a directing metalating group (DMG) with a lithium reagent in anhydrous solvent at low temperature gives the corresponding lithium intermediates in-situ, which on reactions with electrophiles produce the corresponding substituted derivatives. The method is simple, general, convenient and often high yielding