In Vivo Cytogenetic Studies on Aspartame

Journal Article

AlSuhaibani, Entissar S. . 2010

• نوع عمل المنشور: ورقة بحثية
• رابط المنشور على الويب: http://www.hindawi.com/journals/ijg/2010/605921/
• الوسوم: Mitotic Index,Aspartame,Chromosomal Aberration
• المجلة \ الصحيفة: Comparative and Functional Genomics
• رقم العدد: ID 605921
• الصفحات: 1-4

مستخلص المنشور

Aspartame (a-Laspartyl-L-phenylalanine 1-methylester) is a dipeptide low-calorie artificial sweetener that is widely used as anonnutritive sweetener in foods and drinks. The safety of aspartame and its metabolic breakdown products (phenylalanine, aspartic acid and methanol) was investigated in vivo using chromosomal aberration (CA) test and sister chromatid exchange (SCE) test in the bone marrow cells of mice. Swiss Albino male mice were exposed to aspartame (3.5, 35, 350 mg/kg body weight).Bone marrow cells isolated from femora were analyzed for chromosome aberrations and sister chromatid exchanges. Treatment with aspartame induced dose dependently chromosome aberrations at all concentrations while it did not induce sister chromatid exchanges. On the other hand, aspartame did not decrease the mitotic index (MI). However, statistical analysis of the results show That aspartame is not significantly genotoxic at low concentration.