Calibrating and benchmarking absolute malignant induction probabilities

Conference Paper

Madkhali, Abdossalam M . 2015

• نوع عمل المنشور: Poster
• الوسوم: Secondary cancer, radiotherapy, modelling
• اسم المؤتمر: National Cancer Research Institute Conference 2015
• عنوان المؤتمر: Liverpool, UK
• تاريخ المؤتمر: الأحد, تشرين الثاني (نوفمبر) 1, 2015
• المنظمة الراعية: NCRI

مستخلص المنشور

More than half of cancer patients receive radiotherapy for radical or palliative purposes. Increasing survival rates in cancer patients make it important to study late side-effects, including secondary radiation-induced cancers. Although a number of predictive models exist, the absolute accuracy of these models in the radiotherapy dose range is limited partly due to scarcity of data and partly by extrapolation beyond historical data bounds. The aim of this work is to investigate conversion of malignant induction probabilities (MIP), which provide useful relative risk estimates, into absolute life time attributable risk estimates (LAR) and excess absolute risk (EAR) by calibrating and benchmarking our models using published outcome data.