أستاذ مساعد | Assistant Professor

العنوان: Building No:- 23, Floor: Level 2, Room No:- 2B 104 | الهاتف: 4679193

CV

التعريف الشخصي: 
In many diseased condition drugs treatment leads to drug-induced cardiac arrhythmia and cardiomyopathy which shows pathological changes in the cardiomyocytes. In cardiomyocytes, Angiotensin II (AngII) triggers cellular signaling by binding to its receptors: angiotensin II type I receptor (AT1R) and angiotensin II type II receptor (AT2R). The physiological effect of Ang II is mainly transduced by its binding with AT1R. Ang II controls electrolyte balance and blood pressure by stimulating the heart to release aldosterone. Ang II is also involved in the development of cardiac hypertrophy, endothelial dysfunction and even organ damage. ROS contribute to all aspects of cellular function including gene expression, proliferation, migration, and cell death. In our current research, oxidative stress plays an important role in drugs-induced cardiomyopathy. Apoptotic pathways and hypertrophic gene may be involved in the pathogenesis of drug-induced cardiomyopathy. Our new research focus on involvement of NF-kB and AMPK signaling pathways in drugs-induced cardiotoxicity.

Faisal Imam, PhD
Assistant Professor
Department of Pharmacology and Toxicology
College of Pharmacy, King Saud University
P.O. Box 2457, Riyadh, 11451
Kingdom of Saudi Arabia

Tel- +966114679193

Email: faisalimam000@gmail.com

Personal Details:      Born on December 15th, 1978, Male, Married.                                  
 
                                    Objective:  To undertake novel research in the field of Pharmacology and Toxicology having prospects in the understanding the mechanisms, cure and prevention of challenging human diseases.
 
                                    Area of Specialization:   Cell biology, Molecular Biology, Protein Biochemistry, Microscopy, Genomics, Clinical Pharmacology, Molecular Toxicology, Free Radical Biology, Podocytes Biology.
                                   
                                    Education
 
2007-2012                   Ph.D, (Pharmacology) Hamdard University, New Delhi, India
                                    Area of Research: Adverse Drug Reaction Monitoring
Thesis Title “Study of the Monitoring of Adverse Drug Reactions to Combination Anti-tubercular Therapy”.
 
2003-2005                   M.Pharm (Pharmacy Practice), Hamdard University, New Delhi, India
Dissertation Title “Monitoring of Adverse Drug Reaction to Anti-hypertensive agents”
 
1999-2003                   B. Pharm (Pharmacy), Hamdard University, New Delhi, India
 
                                    Position and Honors
 
                                    Positions and Employment
 
03/2013–Present         Assistant Professor & Researcher, King Saud University, Riyadh, KSA.
09/2011–03/2013        Assistant Professor, Translam Institute of Pharmaceutical Education and Research, (Maha Maya Technical University), Meerut, INDIA.
03/2011–09/2011        Assistant Professor, Saroj Institute of Technology and Management, (Gautam Budha Technical University), Lucknow, INDIA.
03/2011–09/2011        Teaching Assistant (Guest lecture), Allied Health Science, (Hamdard University), New Delhi, INDIA.
09/2005–01/2007        Worked as Scientist–II (CRA) in the Department of Clinical research at Torrent Research Centre, Gandhi Nagar, Gujarat, India.
 
Fellowships held
 
1999-2003                   Fellowship in B. Pharm from Central Wakf Council, Govt. Of India, India.
 
Honors and Awards
 
2003:               Qualified GATE examination with 79.49 percentile conducted by IIT Chennai in 2003

 
Academic activity
 
2011-2013:      Supervised postgraduate students of Pharmacology & Toxicology, in fulfillment of their Dissertations as co-supervisor.
 
Publications
 

  1. Imam F, Al-Harbi NO, Al-Harbi MM, Korashy HM, Ansari MA, Sayed-Ahmed MM, Nagi MN, Iqbal M, Khalid Anwer M, Kazmi I, Afzal M, Bahashwan S. Rutin Attenuates Carfilzomib-Induced Cardiotoxicity Through Inhibition of NF-κB, Hypertrophic Gene Expression and Oxidative Stress. Cardiovasc Toxicol. 2015; Dec 26. [Epub ahead of print].          * Corresponding author                  (Impact factor: 1.721)

 

  1. Imam F, Al-Harbi NO, Al-Harbi MM, Ahmad SF, Ansari MA, Zoheir KMA, Iqbal M, Anwer K, Ali Alhoshani A, Attia SM. Diosmin downregulates the expression of T cell receptors, pro-inflammatory cytokines and NF-kB activation against LPS-induced acute lung injury in mice. Pharmacol Res. 2015; 102:1-11.                                                                                                * Corresponding author        (Impact factor: 4.046)

 

  1. Bhat MA, Al-Omar MA, Ansari MA, Zoheir KM, Imam F, Attia SM2, Bakheet SA2, Nadeem A2, Korashy HM2, Voronkov A3,4,5, Berishvili V3, Ahmad SF. Design and Synthesis of N-Arylphthalimides as Inhibitors of Glucocorticoid-Induced TNF Receptor-Related Protein, Proinflammatory Mediators, and Cytokines in Carrageenan-Induced Lung Inflammation. J Med Chem. 2015;58(22):8850-67.             (Impact factor: 5.447)

 

  1. Al-Harbi NO, Imam F, Al-Harbi MM, Ahmad SF, Ansari MA, Zoheir KMA, Sayed-Ahmed MM, Attia SM. Dexamethasone attenuates LPS-induced acute lung injury through Inhibition of NF-kB, COX-2 and pro-Inflammatory mediators and augmentation of anti-Inflammatory Cytokine. Toxicol Appl Pharmacol. (unpublished)                   * Corresponding author                                                           (Impact factor: 3.630)

 

  1. Al-Harbi NO, Nadeem A, Al-Harbi MM, Imam F, Al-Shabanah OA, Ahmad SF, Sayed-Ahmed MM, Bahashwan SA. Oxidative airway inflammation leads to systemic and vascular oxidative stress in a murine model of allergic asthma. Int Immunopharmacol. 2015; 26(1): 237-45.               (Impact factor: 2.472)

 

  1. Iqbal M, Khalil NY, Imam F, Khalid Anwer M. A validated high-throughput UHPLC-MS/MS assay for accurate determination of rivaroxaban in plasma sample. J Thromb Thrombolysis. 2015; 39(1): 79-88.

(Impact factor: 2.039)
 

  1. Al-Harbi NO, Imam F, Al-Harbi MM, Iqbal M, Nadeem A, Al-Shahrah OA, Korashy HM, Al-Hosaini KA, Ahmed M, Bahashwar S. Treatment with aliskiren ameliorates tacrolimus-induced nephrotoxicity in rats. J Renin Angiotensin Aldosterone Syst. 2014 Apr 15.             * Corresponding author (Impact factor: 2.400)

 

  1. Al-Harbi NO, Imam F, Nadeem A, Al-Harbi MM, Iqbal M, Rahman S, Al-Hosaini KA, Bahashwan S. Protection against tacrolimus-induced cardiotoxicity in rats by olmesartan and aliskiren. Toxicol Mech Methods. 2014; 24(9):697-702.                                      * Corresponding author (Impact factor: 1.517)

 

  1. Al-Harbi NO, Imam F, Nadeem A, Al-Harbi MM, Iqbal M, Ahmad SF. Carbon tetrachloride-induced hepatotoxicity in rat is reversed by treatment with riboflavin. Int Immunopharmacol. 2014; 21(2): 383-388.                                                                                      * Corresponding author (Impact factor: 2.472)

 

  1. Al-Harbi NO, Imam F, Al-Harbi MM, Iqbal M, Nadeem A, Sayed-Ahmed MM, Alabidy AD, Almukhallafi AF. Olmesartan Attenuates Tacrolimus-Induced Biochemical and Ultrastructural Changes in Rat Kidney Tissue. Biomed Res Int. 2014; 2014: 607246.                       * Corresponding author (Impact factor: 2.706)

 

  1. Nadeem A, Siddiqui N, Alharbi NO, Alharbi MM, Imam F. Acute glutathione depletion leads to enhancement of airway reactivity and inflammation via p38 MAPK-iNOS pathway in allergic mice. Int Immunopharmacol. 2014; 22(1): 222-229                                                       (Impact factor: 2.472)

 

  1. Nadeem A, Siddiqui N, Alharbi NO, Alharbi MM, Imam F, Sayed-Ahmed MM. Glutathione modulation during sensitization as well as challenge phase regulates airway reactivity and inflammation in mouse model of allergic asthma. Biochimie. 2014; 103: 61-70.                                            (Impact factor: 3.123)

 

  1. Saleem S, Shaharyar MA, Khusroo MJ, Ahmad P, Rahman R, Ahmad K, Alam MJ, Al-Harbi NO, Iqbal M, Imam F. Anticancer potential of rhamnocitrin 4′-β-d-galactopyranoside against N-diethylnitrosamine-induced hepatocellular carcinoma in rats. Molecular and cellular biochemistry. 2013; 384(1-2): 147-153.

                                                                                                                                       (Impact factor: 2.388)
 

  1. Kazmi I, Afzal M, Rahman S, Iqbal M, Imam F, Anwar F. Antiobesity potential of ursolic acid stearoyl glucoside by inhibiting pancreatic lipase. European J Pharmacology. 2013; 709(1-3):28-36.

                                                                                                                                       (Impact factor: 2.684)
 

  1. Afzal M, Kazmi I, Khan R, Singh R, Pravez M, Imam F, Anwar F. Pharmacological Evaluation of Gatifloxacin in Chemically Induced Hepatocarcinogenesis: A New Tool for Hepato-cellularcarcinoma Treatment. Journal of Cancer Science & Therapy. 2013; 5(1): 18-22.                  (Impact factor: 4.203*)

 

  1. Ali MS, Alam MS, Imam F, Siddiqui MR. Topical nanoemulsion of turmeric oil for psoriasis: characterization, ex vivo and in vivo assessment. International Journal of Drug Delivery. 2012; 4(2): 184-197.                                                                                                        (Impact factor: 1.290)
  2. Afzal M, Gupta G, Kazmi I, Rahman M, Upadhyay G, Ahmad K, Imam F, Pravez M, Anwar F. Evaluation of anxiolytic activity of embelin isolated from Embelia ribes. Biomedicine & Aging Pathology. 2012; 2(2): 45-47.

 

  1. Santanu M, Ravinder KM, Munsab A, Manju S, Najmi AK, Faisal I. Associated socioeconomic status with illness behavior in tuberculosis patients undergoing DOTS therapy. Indian Journal of Pharmacy Practice. 2012; 5(3): 45-48.

 

  1. Alam MS, Ali MS, Alam N, Alam MI, Anwer T, Imam F, Daud M, Ali MRS, Shamim M. Design and Characterization of Nanostructure Topical Gel of Betamethasone Dipropionate for Psoriasis. Journal of Applied Pharmaceutical Science. 2012; 2(10): 148-158.

 

  1. Ansari MS, Khayyam UK, Sharma M, Imam F, Behera D. The role of socio-economic factors responsible for non-compliance of directly observed treatment short-course among tuberculosis patients. Journal of Medicine and Health Sciences. 2011; 18(2): 78-86.

 

  1. Khayyam UK, Muzammil S, Imam F. Distribution of obesity among male and female population based on body mass index and relative body weight. J Hosp. Clin. Pharmacy. 2011; 1(2): 1-6.

 

  1. Khayyam UK, Muzammil S, Imam F, Ali M, Anjum R, Anwer MK. An epidemiological study of obesity according to physical activity and family history of disease. J Hosp. Clin. Pharmacy. 2010; 1(1): 1-7.

 

  1. Khalid UK, Imam F, Sharma M, Pillai K, Sarin R, Behera D. Pyrazinamide Induced Maculopapular Rash: The Commonly Used First Line Antitubercular Drug. Indian J. Dermatology. 2010: 55(4): 384-86.

                                                                                                                                    * Corresponding author
 

  1. Anwer T, Sharma M, Iqbal M, Imam F, Pillai KK. Comparative analysis of the protective effects of Melatonin and Silamarine on lipid peroxidation and Dyslipidemia in STZ-induced diabetic rats. Hamdard Medicus. 2009; 52(3): 58-61

 

  1. Sharma M, Khayyam UK, Kumar V, Imam F, Pillai KK, Behera D. Influence of Honey on Adverse Drug Reactions due to Anti-tuberculosis Drugs in Pulmonary Tuberculosis Patients. Cont. J Pharmacol. Toxicol. Research. 2008; 2: 6-11.

 

  1. Sharma H, Aqil M, Imam F, Hussain A, Alam MS, Kapur P, Pillai KK, A Pharmacovigilance Study in the department of medicine of a University teaching hospital. Pharmacy Practice. 2007; 5: 46-49

 

  1. Aqil M, Imam F, Hussain A, Kapur P, Pillai KK. A Pharmacovigilance Study for Monitoring Adverse Drug Reactions with Antihypertensive Agents at a South Delhi Hospital. Int. J Pharmacy Pract. 2006; 14 (4): 311-13.

 
 Invited Review
 

  1. Imam F, Anwer MK, Iqbal M, Alam M, Khayyam UK, Sharma M. Tuberculosis: Brief overview and its shifting paradigm for management in India. Int. J Pharmacol. 2010; 1(1): 755-783.  

 
Research Expertise
 

Clinical Study Bioavailability (BA)/Bioequivalence (BE) Study design, Protocol preparation as per the region specific guidelines using in-house SOP. Actively involved in volunteers recruitment and screening procedure, BA/BE study monitoring etc.
 
Rats/Mouse work Worked maily on Wistar albino rats and BALB/C mouse.
Molecular Biology Isolation of RNA from blood samples and Tissue, Isolation of protein from tissues, cDNA Synthesis, RT-PCR, SDS-PAGE.
 
Protein Biochemistry Thin Layer Chromatography (TLC), Paper Chromatography, ELISA. 
 
Biochemistry Estimation of Protein, Glucose, Cholesterol, Bilirubin, Creatinin, Estimation of oxidative stress markers, Estimation of Nitric oxide, Estimation of Angotensine Converting Enzyme (ACE). SGPT, SGOT, Alkaline Phosphatase, Monoamine Oxididase, Na+-K+ ATPase,
 
Microscopy Light microscopy.
 
Toxicology Estimations of oxidative stress markers such as Glutathione Reductase (GR), Glutathione peroxidase (GPx), Catalase, Glutathione-S-Transferase (GST), lipid peroxidation.
 
Biostatistics Well versed with basic Biostatistical analysis. Microsoft excel, GraphPad Prism, SPSS, etc
 
Computer Skill Proficiency in working with MS office, Excel, Power Point, Ensembel Drug Search Data Base, Micromedex etc.
Instrument Operation:
 		 ELISA Reader, UV Spectrophotometer (Perkin Elmer, Shimadzu), centrifuges, Western blotting and SDS gel electrophoresis units (BIORAD), Ultracentrifuges (Beckman Coulter), Microscopes (Zeiss wide-field microscope, Olympus) etc.

 
PhD Work Summery
 
The work was carried out as part of doctoral thesis was on Adverse Drug Reaction monitoring at LRS Institute of Tuberculosis and Respiratory Diseases (DOTS centers) under RNTCP. 
 
Present Research Summary
 In many diseased condition drugs treatment leads to drug-induced cardiac arrhythmia and cardiomyopathy which shows pathological changes in the cardiomyocytes. In cardiomyocytes, Angiotensin II (AngII) triggers cellular signaling by binding to its receptors: angiotensin II type I receptor (AT1R) and angiotensin II type II receptor (AT2R). The physiological effect of Ang II is mainly transduced by its binding with AT1R. Ang II controls electrolyte balance and blood pressure by stimulating the heart to release aldosterone. Ang II is also involved in the development of cardiac hypertrophy, endothelial dysfunction and even organ damage. On the basis of biochemical investigation and histopathological results, our earlier studies suggested that CK-MB, troponin-I, LDH levels in the blood are early signs of drugs-induced cardiomyopathy. Levels MDA, GSH and increased GPx, GR and Catalase activity showed the mechanism of drug-induced cardiomyopathy. ROS contribute to all aspects of cellular function including gene expression, proliferation, migration, and cell death. Current study is aimed at investigating the hypothesis that endothelial dysfunction, and hypertrophy are the main cause of drug induced cardiomyopathy. Apoptotic pathways and hypertrophic gene may be involved in the pathogenesis of drug-induced cardiomyopathy. This will provide important information to understand the molecular mechanisms leading to the development of drug-induced cardiomyopathy that will reveal new therapeutic approaches.
 
References
Dr. Hesham M Korashy, PhD
Associate Professor
Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University
P.O. Box: 2457, Riyadh 11451, KSA Tel: +966114678038; Email:  hkorashy@ksu.edu.sa
 
Dr. Muzaffar Iqbal, PhD
Assistant Professor, Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University
P.O. Box: 2457, Riyadh 11451, KSA, Tel: +966114697565; Email: muziqbal@gmail.com