أستاذ مشارك | Scientific Director, Prince Naif center for Immunology Research

العنوان: 28214, Outpatients Clinics Bldg

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Publications

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  1. Roua Al-Kufaidy, Alejandro Vazquez-Tello, Ahmed S. BaHammam, Qutayba Hamid, Saleh Al-Muhsen, and Rabih Halwani*. IL-17 enhances the migration of B cells during asthma by inducing CXCL-13 chemokine production in structural lung cells. JACI, Sept. 14, 2016. (IF: 12.5)
  2. Rabih Halwani*, Asma Sultana, Sibtain Afzal, Saleh Al-Muhsen, Achraf Al Faraj. Novel anti-IL-4Ra nanocarrier approach for the efficient control of lung tissue inflammation during asthma. Experimental and molecular medicine. Accepted. In press (Nature group) (*corresponding author), April, 2016.
  3. Khalid M. Alkharfy, Basit L. Jan, Sibtain Afzal, Fahad I. Al-Jenoobi, Abdullah M. Al-Mohizea, Saleh Al Muhsen, Rabih Halwani, Mohammad K. Parvez, Mohammed S. Al-Dosari. Prevalence of UDP-glucuronosyltransferase Polymorphisms (UGT1A6∗2, 1A7∗12, 1A8∗3, 1A9∗3, 2B7∗2, and 2B15∗2) in a Saudi Population. Saudi Pharmaceutical Journal · June 2016
  4. Ratemi E, Sultana Shaik A, Al Faraj A, Halwani R*. Alternative approaches for the treatment of airway diseases: focus on nanoparticle medicine. Clin Exp Allergy. 2016 Aug;46(8):1033-42. Review. (*corresponding author)
  5. Alkhayal KA, Awadalia ZH, Vaali-Mohammed MA, Al Obeed OA, Al Wesaimer A, Halwani R, Zubaidi AM, Khan Z, Abdulla MH. Association of Vitamin D Receptor Gene Polymorphisms with Colorectal Cancer in a Saudi Arabian Population. PLoS One. 2016 Jun 16;11(6):e0155236.
  6. Halwani R, Sultana A, Al-Kufaidy R, Jamhawi A, Vazquez-Tello A, Al-Muhsen S. Th-17 regulatory cytokines inhibit corticosteroid induced airway structural cells apoptosis. Respir Res. 2016 Jan 16;17(1):6.
  7. Al Faraj A, Shaik AS, Ratemi E, Halwani R. Combination of drug-conjugated SWCNT nanocarriers for efficient therapy of cancer stem cells in a breast cancer animal model. J Control Release. 2016 Jan 29;225:240-251.
  8. Al Faraj A, Shaik AS, Afzal S, Al-Muhsen S, Halwani R. Specific targeting and noninvasive magnetic resonance imaging of an asthma biomarker in the lung using polyethylene glycol functionalized magnetic nanocarriers. Contrast Media Mol Imaging. 2015 Dec 28. 
  9. Binkhathlan Z, Badran MM, Alomrani A, Aljuffali IA, Alghonaim M, Al-Muhsen S, Halwani R, Alshamsan A. Reutilization of Tacrolimus Extracted from Expired Prograf® Capsules: Physical, Chemical, and Pharmacological Assessment. AAPS PharmSciTech. 2015 Oct 16. 
  10. Al Faraj A, Shaik AS, Al Sayed B, Halwani R, Al Jammaz I. Specific targeting and noninvasive imaging of breast cancer stem cells using single-walled carbon nanotubes as novel multimodality nanoprobes. Nanomedicine (Lond). 2016 Jan;11(1):31-46.
  11. D'Amato G, Holgate ST, Pawankar R, Ledford DK, Cecchi L, Al-Ahmad M, Al-Enezi F, Al-Muhsen S, Ansotegui I, Baena-Cagnani CE, Baker DJ, Bayram H, Bergmann KC, Boulet LP, Buters JT, D'Amato M, Dorsano S, Douwes J, Finlay SE, Garrasi D, Gómez M, Haahtela T, Halwani R, et al. Meteorological conditions, climate change, new emerging factors, and asthma and related allergic disorders. A statement of the World Allergy Organization. World Allergy Organ J. 2015 Jul 14;8(1):25.
  12. Al Faraj A, Shaik AS, Halwani R, Alfuraih A. Magnetic Targeting and Delivery of Drug-Loaded SWCNTs Theranostic Nanoprobes to Lung Metastasis in Breast Cancer Animal Model: Noninvasive Monitoring Using Magnetic Resonance Imaging. Mol Imaging Biol. 2015 Oct 20. 
  13. Satoshi Okada, Janet G. Markle, Elissa K. Deenick, Federico Mele, Dina Averbuch, Macarena Lagos, Mohammed Alzahrani, Saleh Al-Muhsen, Rabih Halwani, et al. Impairment of immunity to Candida and Mycobacterium in humans with bi-allelic RORC mutations. Science, 2015 Aug 7;349(6248):606-13
  14. Alexandra Y. Kreins, Ciancanelli MJ, Okada S, Kong XF, Ramírez-Alejo N, Kilic SS, El Baghdadi J, Nonoyama S, Mahdaviani SA, Ailal F, Bousfiha A, Mansouri D, Nievas E, Ma CS, Rao G, Bernasconi A, Sun Kuehn H, Niemela J, Stoddard J, Deveau P, Cobat A, El Azbaoui S, Sabri A, Lim CK, Sundin M, Avery DT,  Rabih Halwani, et al. Human TYK2 deficiency: Mycobacterial and viral infections without hyper-IgE syndrome. J Exp Med. 2015 Sep 21;212(10):1641-62.
  15. Al-Muhsen S, Horanieh N, Dulgom S, Aseri ZA, Vazquez-Tello A, Halwani R, Al-Jahdali H. Poor asthma education and medication compliance are associated with increased emergency department visits by asthmatic children. Ann Thorac Med. 2015 Apr-Jun;10(2):123-31.
  16. Rabih Halwani, Roua M. S. Alkufeidy, Mary Angeline Pureza, Alejandro Vazquez-Tello, Ahmed Bahammam, Hamdan Al-Jahdali, Qutayba Hamid and Saleh Al-Muhsen. Role of IL-17 in the Recruitment of B cells into bronchial tissue of asthmatic patients. PLOS ONE, 2014 Dec 10;9
  17. Al-Muhsen S, Vazquez-Tello A, Jamhawi A, Al-Dosari MS, Mahboub B, Iqbal N, Temsah MH, Al-Eyadhy A, Alharbi N, Halwani R. Rs37972 and rs37973 single-nucleotide polymorphisms in the glucocorticoid-inducible 1 gene are not associated with asthma risk in a Saudi Arabian population. J Asthma. 2014 Aug 29:1-8.
  18. Saleh Al-Muhsen, Alejandro Vazquez-Tello, Amer Jamhawi, Sibtain Afzal, Mohamed S. Al-Dosari, Hamdan Al-Jahdali, Ahmed Bahammam, Abdulrahman Alfrayh, Bassam Mahboub, and Rabih Halwani. Association of the STAT6 rs324011 (C2892T) but not rs324015 (G2964A) with atopic asthma in a Saudi Arabian population. Hum Immunol. 2014 Aug;75(8):791-52014.
  19. A. Al Faraj, A. Sultana Shaik, S. Afzal, B. Al Sayed, R. Halwani: MR Imaging and targeting of a specific alveolar macrophage subpopulation in COPD animal model using antibody conjugated magnetic nanoparticles. Int J Nanomedicine. 2014 Mar 24;9:1491-503.
  20. A. Al Faraj, A. Sultana Shaik, M.A. Pureza, M. Alnafea, R. Halwani: Preferential macrophage recruitment and polarization in LPS-induced animal model for COPD: Noninvasive tracking using MRI. PLoS One. 2014 Mar 5;9
  21. Saleh Al-Muhsen, Alejandro Vazquez-Tello, Amer Jamhawi, Mohamed S. Al-Dosari, Hamdan Al-Jahdali, Ahmed Bahammam, Abdulrahman Alfrayh, Sibtain Afzal, Bassam Mahboub, Nouf Al-Khamis and Rabih Halwani. IL-4 Receptor Alpha single nucleotide polymorphisms rs1805010 and rs1801275 are associated with increased risk of asthma in a Saudi Arabian population. Ann Thorac Med. 2014 Apr;9(2):81-6
  22. Ahmed AE, Al-Jahdali H, Al-Harbi A, Khan M, Ali Y, Al Shimemeri A, Al-Muhsen S, Halwani R. Factors associated with poor asthma control among asthmatic patient visiting emergency department. Clin Respir J. 2014 Oct;8(4):431-6. 
  23. Mohammed Al-Dosari, Fahad Al-Jenoobi, Khalid M. Alkharfy, Amal Alghamdi, Khawla Bagulb, Parvez MK, Abdullah Al-Mohizea, Saleh Al-Muhsen, and Rabih Halwani. High Prevalence of CYP2D6*41 (G2988A) Allele in Saudi Arabians. Environ Toxicol Pharmacol. 2013 Sep 21;36(3):1063-1067.
  24. Zainab Hamad, Abdullah Aljedai, Rabih Halwani, Abdulrahman Alsultan. UGT1A1 Promoter Polymorphism associated with serum bilirubin level in Saudi patients with sickle cell disease. Ann Saudi Med. 2013 Jul-Aug; 33(4):372-6.
  25. Khalid M. Alkharfy, Amal Alghamdi, Khawla Bagulb, Fahad Al-Jenoobi, Abdullah Al-Mohizea, Saleh Al-Muhsen, Rabih Halwani, Parvez MK, Mohammed Al-Dosari. Distribution of selected gene polymorphisms of UGT1A1 in a Saudi population. Arch Med Sci. 2013 Aug 30;9(4):731-8.
  26. Mohammed Al-Dosari, Khalid M. Alkharfy, Amal Alghamdi, Abdullah Al-Mohizea, Fahad Al-Jenoobi, Saleh Al-Muhsen, Rabih Halwani, MK Parvez. Genetic Variability of PXR in Saudi Arabians. Biochem Genet. 2013 Aug;51(7-8):575-87.
  27. Saleh Al-Muhsen, Severine Letuve , Alejandro Vazquez-Tello, Mary Angeline Pureza, Hamdan Al-Jahdali, Qutayba Hamid, and Rabih Halwani (Corresponding Author). Th17 Cytokines Induce Pro-fibrotic Cytokines Release From Human Eosinophils. Respiratory Research. 2013 Mar 13;14:34.
  28. Hamdan AL-Jahdali, Ahmed Anwar, Abdullah AL-Harbi, Mohd Khan, Salim Baharoon, Salih Bin Salih, Rabih Halwani and Saleh Al-Muhsen. Improper inhaler technique is associated with poor asthma control and frequent Emergency Department visits. Allergy, Asthma & Clinical Immunology, 2013 Mar 6;9(1):8.
  29. Carolina Prando, Arina Samarina, Jacinta Bustamante, Stéphanie Boisson-Dupuis, Aurelie Cobat, Capucine Picard , Sami Al-Hajjar, Rabih Halwani, Laurent Abel, Davood Mansouri, Ridha Barbouche, Saleh Al-Muhsen, Jean-Laurent Casanova. lnherited IL-12p40 deficiency: genetic, immunological, and clinical features of 49 patients from 30 kindreds. Medicine. 2013 Mar;92(2):109-22.
  30. Rabih Halwani, Saleh Al-Muhsen, and Qutayba Hamid. Th17 cells in airway diseases: from lab bench to bedside. Chest. 2013 Feb 1;143(2):494-501.
  31. Rabih Halwani, Monica Vaccari (co-first), Genoveffa Franchini, and Rafick-Pierre Sekaly. DNA vaccination regimen which includes boosting with MVA induces better memory T cell maintenance compared to boosting with Adenovirus through the down regulation of PD-1 expression on T cells. Journal of Virology. 2013 Jan 16.
  32. Mohamed El-Far,  Catherine Isabelle, Nicolas Chomont, Martin Bourbonnière, Simone Fonseca, Petronela Ancuta, Yoav Peretz, Younes Chouikh, Rabih Halwani, Olivier Schwartz, Joaquín Madrenas, Gordon J. Freeman, Jean-Pierre Routy, Elias K. Haddad and Rafick-Pierre Sékaly. Down-regulation of CTLA-4 by HIV-1 Nef protein. PLoS One. 2013;8(1):e54295. 
  33. Rabih Halwani, Alejandro Vazquez-Tello, Yuki Sumi, Mary Angeline Pureza, Ahmed Bahammam, Hamdan Al-Jahdali, Abdelillah Soussi-Gounni, Bassam Mahboub, Saleh Al-Muhsen, and Qutayba Hamid. Eosinophils Induce Airway Smooth Muscle Cell Proliferation. J Clin Immunol. 2012 Nov 23.
  34. Vazquez-Tello A, Halwani R, Hamid Q, Al-Muhsen S. Glucocorticoid Receptor-Beta Up-Regulation and Steroid Resistance Induction by IL-17 and IL-23 Cytokine Stimulation in Peripheral Mononuclear Cells. J Clin Immunol. 2012 Nov 16.
  35. Hamdan AL-Jahdali, Ahmed Anwar, Abdullah AL-Harbi, Salim Baharoon, Rabih Halwani, Abdulllah Al Shimemeri and Saleh Al-Muhsen. Factors associated with patient visits to the emergency department for asthma therapy. BMC Pulmonary Medicine, 2012 Dec 17;12(1):80
  36. Al-Mohizea AM, Alkharfy KM, Bagulb KM, Alghamdi AM, Al-Jenoobi FI, Al-Muhsen S, Halwani R, Parvez MK, Al-Dosari MS. Genetic variability and haplotype profile of MDR1 in Saudi Arabian males. Mol Biol Rep. 2012 Nov 11.
  37. Al-Khayyat AI, Al-Anazi M, Warsy A, Vazquez-Tello A, Alamri AM, Halwani R, Alangari A, Al-Frayh A, Hamid Q, Al-Muhsen S. T1 and T2 ADAM33 single nucleotide polymorphisms and the risk of childhood asthma in a Saudi Arabian population: a pilot study. Ann Saudi Med. 2012 Sep;32(5):479-86.
  38. Al-Jenoobi FI, Alkharfy KM, Alghamdi AM, Bagulb KM, Al-Mohizea AM, Al-Muhsen S, Halwani R, Parvez MK, Al-Dosari MS. CYP2C19 Genetic Polymorphism in Saudi Arabians. Basic Clin Pharmacol Toxicol. 2012 Jul 3.
  39. Al-Jahdali H, Waness A, Al-Jawder S, Baharoon SA, Al-Muhsen S, Al-Mobeireek A, Salama R,Halwani R. Eosinophilic pneumonia: experience at two tertiary care referral hospitals in Saudi Arabia. Ann Saudi Med. 2012 Jan-Feb;32(1):32-6.
  40. Vazquez-Tello A, Halwani R, Li R, Nadigel J, Bar-Or A, Mazer BD, Eidelman DH, Al-Muhsen S, Hamid Q. IL-17A and IL-17F expression in B lymphocytes. Int Arch Allergy Immunol. 2012;157(4):406-16.
  41. Sancho-Shimizu V, Pérez de Diego R, Lorenzo L, Halwani R, Alangari A, Israelsson E, Fabrega S, Cardon A, Maluenda J, Tatematsu M, Mahvelati F, Herman M, Ciancanelli M, Guo Y, AlSum Z, Alkhamis N, Al-Makadma AS, Ghadiri A, Boucherit S, Plancoulaine S, Picard C, Rozenberg F, Tardieu M, Lebon P, Jouanguy E, Rezaei N, Seya T, Matsumoto M, Chaussabel D, Puel A, Zhang SY, Abel L, Al-Muhsen S, Casanova JL. Herpes simplex encephalitis in children with autosomal recessive and dominant TRIF deficiency. J Clin Invest. 2011 Dec;121(12):4889-902.
  42. Oliveinstein R, Al Jahdali H, Alkhamis N, Halwani R, Al-Muhsen S, Hamid Q. Challeges in the management of severe asthma: role of current and future therapies. Curr Pharm Des. 2011;17(7):703-11. Review.
  43. Rabih Halwani, Al-Abri J, Beland M, Al-Jahdali H, Halayko AJ, Lee TH, Al-Muhsen S, Hamid Q.” CC and CXC chemokines induce airway smooth muscle proliferation and survival.” J Immunol. 2011 Apr 1;186(7):4156-63.
  44. Kong XF, Ciancanelli M, Al-Hajjar S, Alsina L, Zumwalt T, Bustamante J, Feinberg J, Audry M, Prando C, Bryant V, Kreins A, Bogunovic D, Halwani R, Zhang XX, Abel L, Chaussabel D, Al-Muhsen S, Casanova JL, Boisson-Dupuis S. A novel form of human STAT1 deficiency impairing early but not late responses to interferons. Blood. 2010 Dec 23;116(26):5895-906.
  45. Rabih Halwani, Saleh Al-Muhsen, and Qutayba Hamid. Airway remodeling in asthma. Curr Opin Pharmacol. 2010 Jun;10 (3):236-45.
  46. Rabih Halwani, Saleh Al-Muhsen, Hamdan AlJAhdali, and Qutayba Hamid. Role of TGF-{beta} in Airway Remodeling in Asthma. Am J Respir Cell Mol Biol. 2010 Jun 4.
  47. Van Grevenynghe J, Halwani R, Chomont N, Ancuta P, Peretz Y, Tanel A, Procopio FA, shi Y, Said EA, Haddad EK, Sekaly RP. Lymph node architecture collapse and consequent modulation of FOXO3a pathway on memory T- and B-cells during HIV infection. Semin Immunol. 2008 Jun;20(3):196-203.
  48. Rabih Halwani, BY Diab, JD Boyer, DB Weiner, and RP Sekaly. 2008. Therapeutic Vaccination with SIV DNA+IL-12, IL-15 induces protective T cell Memory Subsets in SIV Infected Macaques. J Immunol. Jun 15;180(12):7969-7979
  49. Rabih Halwani, Mehrnoosh Doroudchi, Mohamed El-Far, Andre Tanel, Yu Shi, Bader Yassine-Diab, Rafick-Pierre Sékaly. 2008. Role of Memory T Cells in Influenza Viral Infection. Anti-Inflammatory and Anti-Allergy Agents in Medicinal Chemistry. Volume 7, Number 2, June 2008 , pp. 87-96(10)
  50. Salha M.D, R. Cheynier, R. Halwani H. Mcgrath, T. Y. Langaee, J. Fournier, M. Parenteau, J. Edgar, D. Ko, A. Sherring, D. Bogdanovic, R. -P. Sekaly and E.W. Rud. 2008. Persistence of oligoclonal CD4 T cell responses in SIV infected macaques resistant to SHIV89.6P superinfection. Virology. Aug 1;377(2):239-47
  51. El-Far M, Halwani R, Said E, Trautmann L, Doroudchi M, Janbazian L, Fonseca S, van Grevenynghe J, Yassine-Diab B, Sékaly RP, Haddad EK. 2008. T-cell exhaustion in HIV infection.  Curr HIV/AIDS Rep. 2008 Feb;5(1):13-9
  52. Trautmann L, Rabih Halwani*, Said EA.*, Janbazian L., Chomont N., EL-Far, M., Breton G., Haddad EK., and RP Sekaly. 2007. PD-1: a critical regulator of T-cell function and a strong target for immunotherapies for chronic viral infections. Current opinion in HIV and AIDS. 2(3):219-227
  53. Ihsan sharif-Askari, Denis Gaucher, Rabih Halwani Rafick-Pierre Sekaly. 2007. P56Lck Tyrosine Promotes Fas-Mediated Apoptosis by Enhancing the Recruitment of Death Signaling Complex to Lipid Rafts. J Biol Chem., Dec 7; 282 (49): 36048-56
  54.  Rabih Halwani, Mehrnoosh Doroudchi, Bader Yassine-Diab, Loury Janbazian, Yu Shi, Elias Said, Rafick-Pierre Sékaly. 2006. Generation and maintenance of human memory cells during viral infection. Springer Semin Immunopathol. 2006 Nov;28(3):197-208.
  55. Rabih Halwani, Cen S., Javanbakht H, Kim S, Shiba K., Musier-Forsyth K., and L. Kleiman. 2004. The Cellular Distribution of Lysyl-tRNA Synthetase and its Interaction with Gag during HIV-1 Assembly. J Virol. 78 (14): 7553-64
  56.  Kleiman, L, R. Halwani, and H. Javanbakht. 2004. tRNALys3: The primer tRNA for reverse transcription in HIV-1. Curr HIV Res. Apr; 2 (2): 163-75. Review.
  57. Javanbakht H, Rabih Halwani, Cen S, Saadatmand J, Musier-Forsyth K, Gottlinger H, and L. Kleiman. 2003. The interaction between HIV-1 gag and human lysyl-tRNA synthetase during viral assembly. J Biol Chem. 278 (30):27644-51
  58. Rabih Halwani, Khorchid A., Cen S., and L. Kleiman. 2003. Rapid localization of Gag/GagPol complexes to detergent-resistant membrane during the assembly of HIV-1. J Virol. 77(7): 3973-84.
  59. Rabih Halwani, Khorchid A.*, Wainberg M.A., and L. Kleiman. 2002. Role of RNA in facilitating Gag/GagPol interaction. J Virol. 76: 4131-4137 (*co-1st auther)
  60. Khorchid A., Javenbakht H., Wise S., Rabih Halwani, Wainberg M.A., and L. Kleiman. 2000. Sequences within Pr160gag-pol affecting the selective packaging of primer tRNALys3 into HIV-1. J. Mol. Biol. 299: 17-26.