Effect of aminoglycoside dosing on magnesium levels in hospitalized patients
Journal Article
M, Alkharfy KM, Alrasheed . 2007
رابط المنشور على الويب:
المجلة \ الصحيفة:
International Journal of Antimicrobial Agents
رقم العدد:
2
رقم الإصدار السنوي:
30
الصفحات:
189-90190
مستخلص المنشور:
Aminoglycosides are bactericidal antibiotics used in the systemic treatment of serious Gram-negative infections. Multiple-daily dosing (MDD) has been the conventional method to administer aminoglycosides; however, use of once-daily dosing (ODD) has gained popularity during the last two decades. This is because ODD has a post-antibiotic effect, at least as effective as MDD, and may actually be less nephrotoxic than more frequent dosing [1]. Aminoglycoside-induced nephrotoxicity generally occurs after 5–7 days of treatment and is present as non-oligouric renal failure with a slow rise in serum creatinine