Protective effect of Morocco carob honey against Lead-Induced anemia and Hepato-Renal toxicity

Journal Article

Fihri, Aicha . 2016

• نوع عمل المنشور: Project
• رابط المنشور على الويب: Protective effect of Morocco carob honey against Lead-Induced anemia and Hepato-Renal toxicity
• الوسوم: Lead, honey, kidney, liver, antioxident
• المجلة \ الصحيفة: Cellular Physiology and Biochemistry
• رقم العدد: 1
• رقم الإصدار السنوي: 39
• الصفحات: 115 to 122

مستخلص المنشور

Background/Aims: Natural honey has many biological activities including protective effect against toxic materials. The aim of this study was to evaluate the protective effect of carob honey against lead-induced hepato-renal toxicity and lead-induced anemia in rabbits. Methods: Twenty four male rabbits were allocated into four groups six rabbits each; group 1: control group, received distilled water (0.1 ml / kg.b.wt /daily); group 2: received oral lead acetate (2 g/kg.b.wt/daily); group 3: treated with oral honey (1g /kg.b.wt/daily) and oral lead (2 g/kg.b.wt/daily), and group 4: received oral honey (1 g/kg.b.wt/daily). Honey and lead were given daily during 24 days of experimentation. Laboratory tests and histopathological evaluations of kidneys were done. Results: Oral administration of lead induced hepatic and kidney injury and caused anemia during three weeks of the exposure. Treatment with honey prevented hepato-renal lead toxicity and ameliorated lead-induced anemia when honey was given to animals during lead exposure. Conclusion: It might be concluded that honey has a protective effect against lead-induced blood, hepatic and renal toxic effects.