Biological response to titanium implants coated with nanocrystals calcium phosphate or type 1 collagen in a dog model

Journal Article

• المجلة \ الصحيفة: Clin. Oral Impl. Res.
• رقم الإصدار السنوي: 24
• الصفحات: 475–483

مستخلص المنشور

Abstract
Objective: The current study aimed to evaluate the osteogenic potential of electrosprayed organic
and non-organic surface coatings in a gap-implant model over 4 and 12 weeks of implantation
into the dog mandible.
Material and methods: Sixteen Beagle dogs received experimental titanium implants in the
mandible 3 months after removal of left premolars (P2, P3 and P4). Three types of implants were
installed in each animal: non-coated implant, nano-CaP coated implant and implant with type 1
collagen coating. Both micro-CT and histomorphometry were used to evaluate peri-implant bone
response after implantation periods of 4 and 12 weeks. The bone area percentage was assessed
histomorphometrically in three different zones (inner: 0–300 lm; middle: 300–600 lm; and outer:
600–1000 lm) around the implant surface. Bone-bridging of the gap was also calculated for each
sample.
Results: Four weeks after implantation, nano-CaP and collagen-coated implants showed
significantly higher bone volume (BV) in the inner zone compared with non-coated implants
(P < 0.05 and P < 0.01). After 12 weeks, histomorphometric analysis showed comparable amounts
of BV between all experimental groups. Also, no significant difference was found in the BV, as
measured using micro-CT, between the implant groups. Absolute bone ingrowth measurements
were highest for collagen-coated implants, but these differences were not significant.
Conclusion: The obtained data failed to provide a consistent favourable effect on bone formation
of the collagen coating over 3 months of implantation. It is concluded that the source of the
collagen as well as the limited osseous environment overshadowed a possible effect of the applied
implant surface modifications. Similarly, the tested nano-apatite surface coating did not improve
peri-implant bone ingrowth into a gap-implant model.