الأبحاث

 

 

Assessment of Dietary Vitamin D on Saudi Type II Diabetic Patients with Hypovitaminosis D in Riyadh City 

 

Abstract

           

Diabetes mellitus (DM) is a major public health problem worldwide and many studies have established that vitamin D deficiency is prevalent among type 1 as well as type 2 diabetics. While several risk factors have been identified, vitamin D deficiency stands not only because of its equally alarming global prevalence, but also because of its multiple physiologic roles that influence normal metabolic functioning. Vitamin D deficiency has been also linked to several chronic diseases in adults, and almost all cardio metabolic risk factors are associated with vitamin D deficiency. This intervention multicenter, one-year clinical study was conducted in Riyadh, Saudi Arabia. This study aimed to determine the chemical assessment of vitamin D level and biological parameters especially insulin resistance of Saudi males and females type 2 diabetic patients on diet during 6 and 12 months. Also aimed to asses dietary vitamin D intake of Saudi type 2 diabetic patients on diet and assess the association of vitamin D level and biological parameters among the sample during 6 and 12 months. To achieve this, 45 Saudi adult (male=21, female=24) aged 21 and above, selected randomly from different primary health centers in Riyadh, KSA.

Demographic, medical and dietary information was collected from each subject using a questionnaire. Anthropometrics were measured. Blood levels of fasting glucose, lipid profile, 25(OH) D and corrected calcium were measured

routinely, 25(OH) D was quantified using enzyme-linked immunosorbent assay (ELISA).

The present study demonstrated that after 12-month with dietary vitamin D supplementation resulted in improvement of several key cardio metabolic parameters including systolic blood pressure, insulin and HOMA-IR. Serum vitamin D was positively associated with HDL-cholesterol, systolic blood pressure, insulin and HOMA-IR, and inversely associated with waist circumstance and diastolic blood pressure. These improvements were more notable in the female rather than male cohort. Serum 25(OH) D did not correlate with sun exposure time as well as both macro- and micronutrient intake.

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