Switching from (R)- to (S)-selective chemoenzymatic DKR of amines involving sulfanyl radical-mediated racemization

Journal Article

ElBlidi, Lahssen . 2010

• رابط المنشور على الويب: Switching from (R)- to (S)-selective chemoenzymatic DKR of amines involving sulfanyl radical-mediated racemization
• الوسوم: Chemoenzymatic dynamic kinetic resolution (DKR), amines, sulfanyl radical-mediated racemization
• المجلة \ الصحيفة: Organic & Biomolecular Chemistry
• رقم العدد: 18
• رقم الإصدار السنوي: 8
• الصفحات: 4165-4168

مستخلص المنشور

Chemoenzymatic dynamic kinetic resolution (DKR) of amines involving sulfanyl radical-induced racemization happened to be the very first switchable DKR process allowing the synthesis of either (R)- or (S)-amides, in good yield and high enantiomeric excess, depending on the nature of the enzyme; the different steps of the development of (S)-selective DKR are discussed.