Characterization and Evaluation of the Improved Performance of Modified Reverse Osmosis Membranes by Incorporation of Various Organic Modifiers and SnO2 Nanoparticles

Reverse osmosis (RO) membranes modified with  nanoparticles of varied concentrations (0.001–0.1 wt.%) were developed via in situ interfacial polymerization (IP) of trimesoyl chloride (TMC) and m-phenylenediamine (MPD) on nanoporous polysulfone supports. The nanoparticles dispersed in the dense nodular polyamide on the polysulfone side. The effects of IP reaction time and  loading on membrane separation performance were studied.

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Anthranilamide–Pyrazolo[1,5-a]pyrimidine Conjugates as p53 Activators in Cervical Cancer Cells

A library of new anthranilamide–pyrazolo[1,5-a]pyrimidine conjugates were designed, synthesized, and evaluated for their anticancer activity in cervical cancer cells such as HeLa and SiHa that possess low levels of p53. All 24 conjugates showed antiproliferative activity, while some of them exhibit significant cytotoxicity. In assays related to cell-cycle distribution, these conjugates induced G2/M arrest in HeLa cells and G1 cell-cycle arrest in SiHa cells.

Chem 103

General Chemistry

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NANO-GOLD SUPPORTED NICKEL MANGANESE OXIDE: SYNTHESIS, CHARACTERISATION AND EVALUATION AS OXIDATION CATALYST

Gold nanoparticles supported on nickel manganese mixed oxide were synthesised by co-precipitation method. The catalytic properties of these materials were investigated for the oxidation of benzyl alcohol using molecular oxygen as an oxidant. It was observed that the calcination temperature and the size of the particle play an important role in the process.

Imbalance between the anti- and pro-inflammatory milieu in blood leukocytes of autistic children

Accumulating evidence suggests an association between immune dysfunction and autism disorders in a significant subset of children. In addition, an imbalance between pro- and anti-inflammatory pathways has been proposed to play an important role in the pathogenesis of several neurodevelopmental disorders including autism; however, the role of anti-inflammatory molecules IL-27 and CTLA-4 and pro-inflammatory cytokines IL-21 and IL-22 has not previously been explored in autistic children.

Gene expression profiling to identify the toxicities and potentially relevant human disease outcomes associated with environmental heavy metal exposure

Heavy metals are the most commonly encountered toxic substances that increase susceptibility to various diseases after prolonged exposure. We have previously shown that healthy volunteers living near a mining area had significant contamination with heavy metals associated with significant changes in the expression of some detoxifying genes, xenobiotic metabolizing enzymes, and DNA repair genes. However, alterations of most of the molecular target genes associated with diseases are still unknown.

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