The major objective of this experiment was to assess the effect of alternate plant protein sources as a replacement for fish meal in feed on the proximate composition of muscle, liver and tissue in Oreochromis niloticus.O. niloticus of average size (average Weight 45.00±1.25 g, total length 13.28±1.42 cm) were stocked in 100 L glass aquarium. Fish were fed with three experimental feeds (A, B and C) and reference commercial feed (D) for 16 weeks. Feed A, B and C was prepared from four different plant sources and fish meal (40 % crude protein).