Aim: This study was undertaken to formulate and evaluate the sustained release (SR) matrix tablet of tizanidine hydrochloride by direct compression technique. Materials and Methods: SR matrix tablets of tizanidine were formulated using polymers such as carrageenan, xanthan gum, and polyethylene oxide (PEO) as releases retardants. All the pre-compressional parameters were found to be within the standard limits. Tablets were evaluated for hardness, friability, thickness, drug content, in-vitro release, and stability studies. In-vitro drug dissolution was studied.

SUMMARY. The unit dose drug distribution system at King Khalid University Hospital in the Riyadh region of Saudi Arabia was evaluated for types of missing medications that leads to key problems in medication delivery .A cross sectional study design was used. Overall 783 (6.2%) incidents of missing doses were documented.