Aim: Detection of the interface between etiological agents of bacteremia and epidemiology. Methods: A total of 164 blood samples were collected from patients infected by bacteremia in King Khalid University Hospital, Riyadh, Saudi Arabia. Special bottles of BACTEC/ALERT PF microbial detection System (BIOMÉRIEUX brand) were used as blood culture bottles with antimicrobial removal systems. Bacterial species were identified using cultural, morphological and standard biochemical tests e.g. the oxidase, catalase and Indole tests.