This study comprises the synthesis and characterization of twenty thiazole-derived carbamates (3a-e), N-substituted amides (8a-h) and carboxamide (10) from 2-aminothiazoles (1a, b) via nucleophilic substitution reactions with activated carbonyl compounds including, chloroformates (2a-d), acid chlorides (7a-e) and glutaric anhydride (9), respectively. Sequential hydrazinolysis of carbamate (3e) and condensation with a variety of aldehydes and ketones (5a-d) afforded the corresponding semicarbazones (6a-d).

This work describes different strategies to desymmetrise 1,4-cyclohexadiene
derivatives with concomitant formation of a quaternary stereogenic centre.
Chapter 1 briefly describes the previous desymmetrisation processes of 1,4-
cyclohexadiene derivatives. Chapter 2 describes the formation of the
quaternary stereogenic centre using achiral cyclohexa-1,4-dienone
derivatives. Stereoselective formation of a quaternary stereogenic centre
was achieved using a chiral sulfinyl group as the stereodirecting influence

The tricyclic core of lycoposerramine S has been synthesised in 10 steps from a symmetrical cyclohexadiene precursor by way of a desymmetrising free-radical cyclisation and iodocyclisation.

 

A series of 2-phenyl-5-alkenyl-1,3,4-oxadiazoles were synthesized in high yields from the corresponding dicarbonylhydrazides through cyclodehydration

A combined experimental and theoretical analysis of on molecular structure, vibrational spectra and
HOMO-LUMO analysis of 1-{3-(4-chlorophenyl)-5-[4-(propan-2-yl)phenyl]-4,5-dihydro-1H-pyrazol-1-
yl}-ethanone is reported. The equilibrium geometry and vibrational wavenumbers have been
computed using desnity functional B3LYP method with 6e311þþG(d) (5D, 7F) as basis set. The nonlinear
optical properties were evaluated by the determination of the first and second hyperpolarizabilities of