BACKGROUND:

We investigated whether polymorphism rs7555523 (A > C) in human transmembrane and coiled-coil domain 1 (TMCO1) gene is a risk factor for primary open angle glaucoma (POAG) in a Saudi cohort.

METHODS:

A cohort of 87 unrelated POAG cases and 94 control subjects from Saudi Arabia were genotyped using Taq-Man® assay. The association of genotypes with POAG and other glaucoma specific clinical indices was investigated.

RESULTS:

AIMS:

To investigate the association between the rs1900004 polymorphism in the atonal bHLH transcription factor 7 (ATOH7) gene and primary open angle glaucoma (POAG) in Saudi patients.

METHODS:

Eighty-seven unrelated POAG cases and 94 unrelated control subjects of Saudi origin were genotyped utilizing a TaqMan® assay. The association between mutant genotypes and POAG and its related clinical indices was investigated.

RESULTS:

AIMS:

To investigate whether the polymorphism rs1063192 (A>G) in the cyclin-dependent kinase Inhibitor-2B (CDKN2B) gene is a risk factor for primary open-angle glaucoma (POAG).

METHOD:

A case-control study was conducted wherein we genotyped 87 unrelated POAG cases and 94 control subjects from Saudi Arabia using the Taq-Man® assay.

RESULTS:

BACKGROUND:

To investigate whether SNP rs4986790 in toll-like receptors (TLRs) is a risk factor for primary open angle glaucoma (POAG) in a Saudi population.

MATERIALS AND METHODS:

A cohort of 85 unrelated POAG patients and 95 unrelated control subjects from Saudi Arabia were genotyped utilizing Taq-Man® assay. The association between mutant genotypes and various clinical indices important for POAG was investigated.

RESULTS:

AIMS:

To investigate whether single nucleotide polymorphism (SNP) rs4986791 (C>T) in the toll-like receptor 4 (TLR4) gene is a risk factor for primary open-angle glaucoma (POAG) in the Saudi population.

METHOD:

A case-control study was performed to genotype a cohort of 85 POAG patients and 95 matched healthy controls utilizing TaqMan(®). The association between mutant genotypes and various POAG clinical indices were investigated.

RESULTS:

AIMS:

To investigate whether the single-nucleotide polymorphism (SNP) rs5743704 in the toll-like receptor 2 gene is associated with primary open-angle glaucoma (POAG) or any of its clinical indices in a Saudi cohort.

METHOD:

Ninety-five unrelated POAG cases and 95 controls of Saudi origin were genotyped utilizing a TaqMan(®) assay. The association between genotypes and various clinical indices important for POAG were investigated.

RESULTS: