ABSTRACT: tSilver nanoparticles (AgNPs) are an important class of nanomaterial used for a wide range of industrial andbiomedical applications. Adenium obesum is a plant of the family Apocynaceae that is rich in toxic cardiacglycosides; however, there is scarce information on the anticancer potential of its AgNPs. We hereinreport the novel biosynthesis of AgNPs using aqueous leaf extract of A. obesum (AOAgNPs). The synthesisof AOAgNPs was monitored by color change and ultraviolet–visible spectroscopy (425 nm).