The reaction of 2-isonicotinoyl-N-cyclohexyl/
arylhydrazinecarbothioamide (2a–r) with sodium hydroxide,
in each case, a single product was obtained. The
structures of the compounds were confirmed on the basis of
their elemental analysis and spectral data. The single
crystal X-ray analysis confirmed the structure of these
products as N-4-cyclohexyl/aryl-5-(pyridine-4-yl)-2,4-
dihydro-3H-1,2,4-triazole-3-thiones (3a–r). The in vitro
antitumor activity of compounds was screened against
three cell lines; BEL-7402, HUH-7 and HepG2 human