N-Arylphthalimides (1−10P) derived from thalidomide
by insertion of hydrophobic groups were evaluated for
anti-inflammatory activity, and (4-(1,3-dioxo-1,3-dihydro-2Hisoindol-
2-yl)-N′-[(4-ethoxyphenyl)methylidene]benzohydrazide
6P was identified as a promising anti-inflammatory agent. Further
testing confirmed that compared with the control, 6P treatment
resulted in a considerable decrease in CD4+, NF-κB p65+, TNF-
α+, IL-6+, GITR+, and IL-17+ cell populations and an increase in

tA simple and sensitive UPLC–MS/MS assay was developed and validated for rapid determination ofthiosemicarbazide derivative of isoniazid (TSC-INH), a potent anti-candidal agent in rat plasma, tissues,urine and feces. All biological samples were prepared by protein precipitation method using celecoxib asan internal standard (IS). Chromatographic separation was achieved on Acquity BEHTMC18(50 × 2.1 mm,1.7 m) column using gradient mobile phase of acetonitrile and water (containing 0.1% formic acid)at flow rate of 0.3 mL/min.

The present approach enumerates the effectiveness of tuftsin tagged nano-liposome for the cytosolic
transport of 2,6-di-isopropylphenol-linolenic acid conjugate against liver cancer in mice. Initially, the
conjugate in its free form was examined for anticancer potential on HepG2 liver cancer cells. Induction of
apoptosis and suppression of migration and adhesion of HepG2 cells confirmed the effectiveness of
conjugate as an anticancer agent. After this, role of the conjugate entrapped in a nano-carrier was