PHC222: Medicinal Chemistry-I

The course is designed to provide the students with the essential fundamentals of medicinal chemistry. The course is focused on the physicochemical properties of drug molecules and the effects those properties have on absorption, distribution, metabolism and interaction with a receptor to give a physiological response. The course also covers fundamental principles of drug metabolism

Textbook:

  1. Patrick, Graham, An Introdcution to Medicinal Chemistry, 5th edition
ملحقات المادة الدراسية

5391 ريض (مواضيع مختارة في الرياضيات)

The course covers selected topics in mathematics suggested by the student's supervisor.

ملحقات المادة الدراسية

The Banach-Lie Algebra of Multiplication Operators on a JBW*-triple

The Banach–Lie algebra L(A) of multiplication operators on the JB∗-triple A is introduced and it is
shown that the hermitian part L(A)h of L(A) is a unital GM-space the base of the dual cone in the dual
GL-space (L(A)h)
∗ of which is affine isomorphic and weak∗-homeomorphic to the state space of L(A). In
the case in which A is a JBW∗-triple, it is shown that tripotents u and v in A are orthogonal if and only if
the corresponding multiplication operators in the unital GM-space L(A)h satisfy
0 D(u, u) +D(v, v) idA,

The Banach-Lie Algebra of Multiplication Operators on a W*-algebra

The hermitian part L(A)h of the Banach-Lie -algebra L(A) of multiplication operators
on the W-algebra A is a unital GM-space, the base of the dual cone in the dual GL-
space (L(A)h) of which is affine isomorphic and weak-homeomorphic to the state
space of L(A). It is shown that there exists a Lie -isomorphism from the quotient
(A 1 Aop)/K of an enveloping W-algebra A 1 Aop of A by a weak-closed Lie
-ideal K onto L(A), the restriction to the hermitian part ((A1Aop)/K)h of which is

Ergodic Convergence of the Double Backward Method for Monotone Operators

The double backward method for nding zeros of the sum of two
maximal monotone operators is investigated. This method was initially intro-
duced by Passty in 1979 who used an equal index to the resolvents of both oper-
ators. In this paper, we use distinct indices in order to see different roles played
by the two operators in the double backward method. Under certain conditions
on the indices, we prove the ergodic convergence of our method.

Properties and splitting method for the p-Elastic Net

The lasso of Tibshirani is a popular model for variable selections.
The elastic net of Zou and Hastie applies Tikhonov's regularization to the
lasso to break some limitations of the lasso in the case where the number of
predictors is much bigger than the number of observations, or where a group
of variables have pairwise high correlations. We generalize the elastic net by
replacing Tikhonov's regularization with a more general `p-norm regularization
which we refer to as the p-elastic net. One diculty for dealing with the p-

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