Information on consumer behavior towards online pharmacy is scarce. This study investigated the consumer’s knowledge and perception towards the use of online pharmacy services in the Riyadh region of Saudi Arabia. The questionnaire survey method was used. A clear majority of the respondents did not hear about online pharmacy (82.6%) and very few respondents purchased medicinal product through online pharmacy (1.4%). Overall, there were knowledge deficits in regards to online pharmacy and purchasing medicines from online pharmacies was not a common practice in this current sample.