Aims and Objectives: To assess the effect of Cobb angle and body mass index (BMI) on surgery recovery outcomes in Adolescent Idiopathic Scoliosis (AIS) patients.

Series of Schiff bases of valproic acid hydrazide, N-valproylglycine hydrazide and N-valproyl-4-aminobenzoyl
hydrazide derivatives were synthesized and characterized by IR, NMR (1H- and 13C-NMR) and
elemental analysis. The prepared compounds were evaluated in transgenic zebrafish embryos (Tg: flil-1: enhanced
green fluorescent protein (EGFP)) for antiangiogenic activity and in HepG2 liver carcinoma cell line
for anti cancer activity. The Schiff bases of N-valproylglycine hydrazide derivatives were most potent in term

Background: Valproic acid (VPA) is a potent anticancer and antiangiogenic agent. However, design and
synthesis of chemical derivatives with improved antiangiogenic and anticancer activities are still necessary. In
this study a library of novel derivatives of VPA was synthesized and tested. Methods: A human liver cancer cell
line (HepG2) and a human normal embryonic kidney cell line (HEK 293) were exposed to various concentrations
of VPA derivatives for 24 hours and cell viability was checked by MTT colorimetric assay. Anti-angiogenic

Pulicaria genus belongs to the family Compositae. Some species of this genus
have been used in traditional Arab medicine as antispasmodic agent. In this study the
Pulicaria glutinosa, which is a wild growing shrub in Saudi Arabia have been explored
for developmental toxicity using zebrafish embryos. The fractionated crude extract showed
diverse biological activity as methanol fraction exhibited highest antioxidant activity
(IC50 12.2±0.27%) followed by chloroform fraction (18.1±0.36%), while hexane fraction

Endophytes associated with Calotropis procera and Phoenix dactylifera were screened for their capacity to produce bioactive metabolites against a panel of cancer cell lines and human pathogens. In the present study, the antiproliferative activity of ethyl acetate extract of MN05 displayed concentration-dependent inhibitory effects against the HepG2 and Jurkat cell lines, with an IC50 of 69.13 and 85.56μg/ml respectively. The extract induced morphological abnormalities in the cells and inhibited cells migration.