Purpose: Cancer is a major health problem worldwide. There is a continuous need to search for safer and more effective alternatives to overcome the side effects and resistance of the chemotherapeutic agents. Therefore, in this study we investigated the antiproliferative activity and the apoptotic potential of Withania somnifera (W. somnifera).

The effects of Cadmium (Cd) exposure and the treatment with Zinc (Zn) on immune functions of
splenocytes and cultured lymphocytes of rats were studied. The exposure of rats to Cd was at a dose
of 2.2 mg/kg CdCl2, injected subcutaneously four times weekly for 2 months. Rats were supplemented
with Zn (2.2 mg/kg ZnCl2, injected subcutaneously four times weekly for 2 months) one hour prior to
Cd exposure. Spleens were removed and splenocytes were isolated and cultured. The proliferation

Eight novel N′-(2-oxoindolin-3-ylidene)-2-propylpentane hydrazide-hydrazone