Silver nanoparticles (SNPs) are widely used in nanomedicine and consuming products with potential risk on human health. While considerable work was carried out on the molecular, biochemical, and physiological alterations induced by these particles, little is known of the ultrastructural pathological alterations that might be induced by nanosilver materials. The aim of the present work is to investigate the hepatocyte ultrastructural alterations that might be induced by SNP exposure.

:MalealbinoWistarratswereexposedto10nmgoldnanoparticlesatadoseof2000µg/kgtogetherwithor withoutpropolis(50mg/kg)for15consecutivedays. Freshrenalbiopsiesfromofallinvestigatedratswerecutrapidly, fixed in neutral buffered formalin, subjected to histological processing, and examined for microanatomical alterations. Propolis gave full protection against glomerular congestion and renal tubule hyaline casts.

Little is known about propolis protective effect against the toxicity induced by gold nanoparticles (GNPs). The present investigation  was carried out to investigate the protective role of propolis against the histological alterations induced in the lung tissues by naked 10 nm GNPs. Male albino Wistar rats were exposed to 10 nm GNPs at a dose of 2 mg/kg together with or without propolis (50 mg/kg) for15 days. Lung biopsies from all rats under study were subjected to histological examinations.

Zinc oxide nanoparticles (ZnO NPs) are widely used in industry and cosmetic products with promising investment in medical diagnosis and treatment. However, these particles may reveal high potential risk for human health with little information is available about their toxicity. The present study was carried out to investigate the ultrastrcutural alterations induced in the hepatic tissues by ZnO NPs. Male Wistar albino rats were exposed to ZnO NPs at a daily dose of 2 mg/kg for 21 days.