BACKGROUND:

A great number of novel compounds with rich chemical diversity and significant bioactivity have been reported from Red Sea sponges.

OBJECTIVE:

To isolate, identify, and evaluate the cytotoxic activity of the chemical constituents of a sponge belonging to genus Haliclona collected from the Eastern coast of the Red Sea.

MATERIALS AND METHODS:

A series of twenty four benzo[g]triazoloquinazolines was prepared and fully characterized in our previous paper. Here, the cytotoxicity of these compounds was evaluated in vitro against three tumor cell lines, i.e. hepatocellular carcinoma (Hep-G2), human cervical cancer (Hela) and medulloblastoma (Daoy). MTT assay was employed to elucidate the cytotoxicity of the target molecules and dasatinib used as reference drug.

IQGAPs genes play critical role in either induction or suppression of cancer and its progression, however the relationship between Ras genes and these genes are still unclear. In this study, we tried to understand the mechanistic action of IQGAPs genes and its correlation with Ras genes in mouse hepatic cancer model. The genetic expressions of IQGAP1, IQGAP2, IQGAP3, Hras, Kras, Nras, Mras, Caspase3, and BAX were followed in both hepatocellular carcinoma and normal liver cells of Balbc mice.

The aim of this study was to investigate the effects of different low-level laser therapies (LLLTs) of various wavelengths and energies on normal cultured human melanocytes. Various studies have shown the effects of LLLs on various types of cultured cells. Presently, little is known about the biological effects of LLLTs on melanocytes. Melanocytes were exposed to LLLT at 0.5, 1.0, 1.5, 2.0, 2.5, 3.0, 3.5, 4.0, 4.5, or 5.0 J/cm(2) using a blue (457 nm), red (635 nm), or ultraviolet (UV) (355 nm) laser.