Objective: To investigate the radioprotecting ability of the extract of the medicinal plant Holarrhena antidysentrica, especially to protect DNA from gamma- radiation induced damages. Materials and Methods: Hydo-alcoholic extract of dried roots of Holarrhena antidysentrica (HAE) was prepared, freeze dried and stored at 40 C. The DNA of the plasmid pBR322 was exposed to gamma-radiation in presence and absence of HAE and subjected to agarose gel electrophoresis to study radioprotecting ability of the extract under in vitro conditions.

Objective: To investigate the molecular mechanism of anti tumor activity of Clerodendron infortunatum extract (CIE) under in vitro condition. Materials and Methods: The cytotoxic activity of CIE extract was tested on murine tumor cells (Dalton’s lymphoma ascites cells - DLA) and normal mouse cells (splenocytes) by trypan blue dye exclusion assay. The ability of the extract to induce apoptosis was measured via acridine orange and propidium iodide dual staining method.

AIM OF STUDY:

The present work aimed to examine the efficacy of two ayurvedic formulations, Brahma Rasayana (BRM) and Chyavanaprash (CHM) to alleviate doxorubicin (DOX) induced acute cardiotoxicity.

MATERIALS AND METHODS:

Swiss albino mice were administered with DOX (25 mg/kg, i.p.) and two doses of BRM or CHM (1 and 2 g/kg). Cardiotoxicity was assessed by measuring the levels of various antioxidant parameters in the heart as well as release of marker enzymes in the serum was assayed. Histology of the heart was also performed to check for DOX-induced damages.

In order to investigate the diversity of ABO and Rh blood group genes in the Saudi Arabian population, we assembled the phenotypic data of approximately 66,000 subjects from ten representative Saudi populations: Al-Khobar, Riyadh, Tabuk/Madina Al-Munawaara, Jeddah, Abha, South region, Sakaka, Domah, Al-Qurayat, and Sweer. The frequencies of p[A], q[B], and r[O] alleles at the ABO locus were observed to be 0.1688, 0.1242, and 0.7070, respectively, and the frequency of the D allele at the Rh locus was 0.7138.

Objective: To evaluate the anti tumor activity of Coscinium
fenestratum extract under in vitro and in vivo conditions. Materials
and Methods: The cytotoxic activity of C. fenestratum extract was
tested on HeLa cells by MTT assay. The apoptosis-inducing activity
of the extract was measured via mitochondtial membrane potential
assay, acridine orange and ethidium bromide dual staining method,
DNA fragmentation assay and caspase assay. The in vivo antitumor
activity of the extract was tested against developed solid tumor in

The aim of this study was to compare the characterization of prostate cancer using the
conventional and 2005 ISUP modified Gleason systems. Materials and Methods: The study employed samples
from 40 prostate cancer patients with resection, biopsy and RP materials. The majority of cases (95%) comprised
adenocarcinoma of the prostate with a modified combined Gleason score of 7 in 20 of the cases (50%). Results:
Upgrading of Gleason scores to a score of 7 occurred in more than 45% of the cases. Conclusion: The study

Acetone (dimethyl ketone) and 2-propanone (CH3COCH3) is an organic chemical compound which belongs
to ketones. Acetone is produced normally in human body, but its excessive levels has toxic hazard
effects. Acetone is used in many fields, but excessively as nail polish remover. Present study results proved acetone
inhalation bad effects (with different concentration levels on experimental male Wistar rats), as neuro-behavior disorders,
lack of red blood cells, biochemical imbalance in glucose and insulin levels, urinary acetone increasing level and

Nanotechnology applications have occurred rapidly. Zinc oxide nanoparticles (ZnO NPs) have useful effects for their less hazards on the environment and for their application usages: paints, cosmetics, biomedicine and food as zinc supplements. ZnO NPs toxic effect is due to their tissue accumulation ability. Four ZnO NPs concentration levels effect was investigated on 75 male Wistar rats submandibular gland for 8 weeks. Treated groups histopathological sections showed progressive atrophy and degenerative changes in acini and striated ducts dilatation.

It is increasingly clear that the three RAS genes, N-. H- and K-RAS, encode 21 kDa proteins which act as
intracellular switches, play a signal transduction pathway in controlling cell growth and differentiation. The three
genes are highly homologous, yet recent evidence suggests they may have distinct functions in different cell types
and have a central role in many human diseases. This article reviews briefly the regulation of signaling mechanisms