Chromosomes can be structurally identified by their sizes, positions of centromeres
and nucleolar organizers, and patterns of chromomeres, heterochromatin,
and bands. There are four types of aberrations in the chromosomal structure such
as deletions, duplications, inversions, and translocations which can be detected
cytologically under the microscope. Some changes are however too subtle to be
detected cytologically. Deletions represent missing segments of chromosomes.
The homozygous deletions can be lethal, whereas heterozygous deletions can be

This review provides a summary and appraisal commentary on the treatment review by Murza, K. A., Nye, C., Schwartz, J. B., Ehren, B. J., & Hahs-Vaughn, D. L. (2014). A randomized controlled trial of an inference generation strategy intervention for adults with high-functioning autism spectrum disorder. American Journal of Speech-Language Pathology, 23(4), 461–473.