The two-machine flowshop environment with sequence-independent setup times has been intensely investigated both from theoretical and practical perspectives in the scheduling literature. Nevertheless, very scant attention has been devoted to deriving effective lower bounding strategies. In this paper, we propose new lower bounds for the total completion time minimization criterion. These bounds are based on three relaxation schemes, namely the waiting time-based relaxation scheme, the single machine-based relaxation scheme, and the Lagrangian relaxation scheme.