Samples from different plants species, which grown around Mahad AD’Dahab Mine, have been selected to study their ability to accumulate these heavy metals. These plant species were: Pergularia tomentosa, Calotropis procera, Acacia tortilis, Ochradenus baccatus, Salsola Sp., Rhiza strica, Convolvalus Sp., Euculeptus Sp., Family Graminaea, and Prosopis juliflora. Moreover, some of soil samples under each plant were collected. Plants and soils samples were analyzed for their contents of As, Cd, Cu, Pb, and Zn.