A new series of 3,4,5-trimethoxyphenyl bearing
pyrazole (4a–g) and pyrazolo[3,4-d]pyridazine (5a–g)
scaffolds were synthesized in good yield. The newly synthesized
compounds were characterized on the basis of
elemental and spectroscopic analyses. Their inhibitory
activity against the pro-inflammatory inducible nitric oxide
synthase and cyclooxygenase-2 proteins expression in
lipopolysaccharide-stimulated murine RAW 264.7 macrophages
were assessed and showed various potencies. All
pyrazolo[3,4-d]pyridazine compounds (5a–g) strongly

New pyrazoline derivatives were synthesized via the reaction of chalcones with cyclohexyl/phenyl
thiosemicarbazide in presence of ethanol and acetic acid. All the compounds were confirmed by FT IR,
1H NMR, 13C NMR and MS spectral data. The compounds (1-11) were evaluated for antifungal activity
against various strains of Candida species and compared with standard drug Itraconazole. MIC50 values
were found to be within the range of 41.099-127.895 μg/ml and MIC90 values were found to be within the

A series of Schiff base derivatives 4a-k were synthesized from 4-amino-3-(4-pyridyl)-5-mercapto-
4H-1,2,4-triazole 3 as starting materials by using microwave irradiation technique. The synthesized
compounds were fully characterized by NMR, FT-IR, elemental analysis, and HR-mass spectra. The
results indicated that the microwave irradiation technique gave higher yields of pure products with
short time of the reaction in compare to the thermal method.

Solubility of dihydropyrimidine derivative 4-(4-ethoxyphenyl)-5-(3,4,5 trimethoxybenzoyl)-3,4-
dihydropyrimidine-2(1H) one (DHP-5), a novel anticancer drug, was experimentally measured in PEG-
400 + water binary solvent mixtures over a temperatures range from 298.15 to 318.15 K. Thermodynamic parameters
including enthalpy, entropy and Gibbs free energy of the solubility data were calculated using van't
Hoff equation. Experimental solubility data was employed to evaluate the relative performance of a number of