Simultaneous determination of erlotinib and tamoxifen in rat plasma using UPLC-MS/MS: application to pharmacokinetic interaction studies

Tamoxifen (TAM) is a non-steroidal estrogen receptor antagonist that enhances erlotinib (ERL)-inducedcytotoxicity in the treatment of NSCLC. ERL and TAM are metabolized by CYP3A4 enzymes. In addition,both drugs have the potential of altering the enzymatic activity through either inhibition (ERL) or induc-tion (TAM). Thus it was expected that pharmacokinetics (PK) drug–drug interactions (DDIs) could beencountered following their co-administration.

An eco-friendly direct spectrofluorimetric method for the determination of irreversible tyrosine kinase inhibitors, neratinib and pelitinib: application to stability studies

A new rapid and simple stability-indicating spectrofluorimetric method has been developed for the determination of two irreversible tyrosine kinase inhibitors (TKIs), neratinib (NER) and pelitinib (PEL). The method is based upon measurement of the native fluorescence intensity of both drugs at λex 270 nm in aqueous borate buffer solutions (pH 10.5). The fluorescence intensity

CSC 590: Mobile Computing

Not Teaching This Course This Semester
1432-1433 Second Semester
CSC 590: Mobile Computing, 3 credit hours
Time: Section 1 (Male) 8:00 A.M. – 11:00 A.M., every Monday
Section 2 (Female) 01:00 P.M. – 04:00 P.M., every Monday
Date : 05-03-1433– 16-07-1433 H.
Location: Room
Instructor: Dr. Iehab AL-Rassan, office phone: 4676585, email: irassan@yahoo.com

ملحقات المادة الدراسية

CSC 329: Computer Networks

Not Teaching This Course This Semester
CSC 329: Computer Networks, 3 credit hours
 
Time:        3:00 P.M. – 5:00 P.M., Sunday, Tuesday                      
Date:            14-10-1430 – 5-2-1431 H.
Location:      Sunday, Tuesday : A 047 
Instructor:   Dr. Iehab AL-Rassan, office phone: 4676585, email:  irassan@yahoo.com

ملحقات المادة الدراسية

CSC 523: Distributed Systems

1438-1439 First Semester

CSC 523: Distributed Systems, 3 credit hours
Time:   Section 1 (Male regular program) 04:00 P.M. – 07:00 P.M., Sunday
            Section 2 (Female regular program) 01:00 P.M. – 04:00 P.M., Monday
Date : 26-12-1438– 10-04-1439 H.

ملحقات المادة الدراسية

CSC 457 Internet Technologies

King Saud University, College of Computer and Information Sciences
Department of Computer Science
 
 
1438-1439 First Semester 
 
CSC 457 Internet Technologies
 
 
 
Time:  Sunday, Tuesday. 2:00-3:50 PM,
Date : 26-12-1438– 10-04-1439 H.
Location: Room 0160 31 1 A 048

ملحقات المادة الدراسية
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