The IL-6/STAT3/NF-κB positive feedback loop links in ammation to cancer and maintains cells at a transformed state. Similarly, cancer-associated myo broblats remains active even in absence of cancer cells. However, the molecular basis of this sustained active state remains elusive. We have shown here that breast cancer cells and IL-6 persistently activate breast stromal broblasts through the stimulation of the positive IL-6/STAT3/NF-κB feedback loop.
The diversity of human perceptions of entertainment coupled with the continuous emergence of new modes of entertainment have raised a challenge in offering the entertainment environment that is properly aligned with the public interest. Entertainment preferences are known to be shaped by a combination of individuals’ social and cultural background, instability in economic situation, and generational differences.
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