Severe hypovitaminosis D is widespread in Saudi adults and is more common in non-diabetics than diabetics
G, Al-Daghri NM, Al-Attas OS, Alokail MS, Alkharfy KM, Al-Yousef M, Nadhrah H, Sabico S, Chrousos . 2010
OBJECTIVES
To compare the incidence of hypovitaminosis D in subjects, with and without type 2 diabetes mellitus (T2DM), and determine its association to various risk factors.
METHODS
Three hundred and forty-one (177 non-diabetic, and 164 T2DM) Saudi adults were included in this cross-sectional study conducted at the Biomarkers Research Program (BRP) of King Saud University, Riyadh, Kingdom of Saudi Arabia from March to August 2009. Anthropometrics and fasting blood samples were obtained. Fasting glucose (FG) and lipid profiles were determined. Serum 25-hydroxy vitamin D (25[OH]D) and parathyroid hormone (PTH) were quantified using enzyme-linked immunosorbent assay. Severe hypovitaminosis D was defined as serum 25(OH)D with levels <12.5 nmol/l.
RESULTS
Age was the most significant predictor of 25(OH)D in both groups, explaining 25% (p=0.0005) and 16% of variances (p=0.0005). Waist-hip ratio, systolic blood pressure and body mass index were significant predictors of 25(OH)D among non-diabetics after age adjustment, explaining 21% of variance perceived (p=0.039). Serum PTH levels were higher in non-diabetic men and women.
CONCLUSIONS
Severe hypovitaminosis D is prevalent in both non-diabetic and diabetic Saudis, but was more common in the young and middle-aged non-diabetics. The study further underscores the need for vitamin D fortification of the Saudi diet, and the promotion of vitamin D supplementation in both groups.
Abstract
Objectives: To assess circulating fetuin A and fetuin B levels in participants with and without Gestational Diabetes Mellitus (GDM) and to find out their correlations with other…