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Reem A. Alajmi

Associate Professor

Vice dean of science collage

كلية العلوم
Bulding 5, 3rd floor, office # 5T005
المنشورات
مقال فى مجلة
2016

The Protective Properties of the Strawberry (Fragaria ananassa) against Carbon Tetrachloride-Induced Hepatotoxicity in Rats Mediated by Anti-Apoptotic and Up regulation of Antioxidant Genes Expression Effects

The strawberry (Fragaria ananassa) has been extensively used to treat a wide range of ailments in many cultures. The present study was aimed at evaluating the hepatoprotective effect of strawberry juice on experimentally induced liver injury in rats. To this end, rats were introperitoneally injected with carbon tetrachloride (CCl4) with or without strawberry juice supplementation for 12 weeks and the hepatoprotective effect of strawberry was assessed by measuring serum liver enzyme markers, hepatic tissue redox status and apoptotic markers with various techniques including biochemistry, ELISA, quantitative PCR assays and histochemistry. The hepatoprotective effect of the strawberry was evident by preventing CCl4-induced increase in liver enzymes levels. Determination of oxidative balance showed that strawberry treatment significantly blunted CCl4-induced increase in oxidative stress markers and decrease in enzymatic and non-enzymatic molecules in hepatic tissue. Furthermore, strawberry supplementation enhanced the anti-apoptotic protein, Bcl-2, and restrained the pro-apoptotic proteins Bax and caspase-3 with a marked reduction in collagen areas in hepatic tissue. These findings demonstrated that strawberry (F. ananassa) juice possessed antioxidant, anti-apoptotic and anti-fibrotic properties, probably mediated by the presence of polyphenols and flavonoids compounds.

رقم المجلد
5
رقم الانشاء
7
مجلة/صحيفة
Front Physiol
الصفحات
325
مزيد من المنشورات
publications
بواسطة Afnan S. Al-Qurashi, Ashraf M. Mashaly, Reem Alajmi, Mohamed S. Al-Khalifa, Lamjed Mansour, Suliman Y. Al-Omar, Mostafa R. Sharaf, Abdulrahman S. Aldawood, Hathal M. Al-Dhafer, Tony Hunter, Masha’el Y. Almutawa, Ashraf M. Ahmed
2023
تم النشر فى:
Journal of Medical Entomology
publications
بواسطة Hend M Alharbi, Yasser A Elnakady, Badr A Aldahmash, Reem Alajmi, Zeid A ALOthman, Ahmed-Yacine Badjah-Hadj-Ahmed, Ahmad Aqel, Ashraf M Ahmed
2023
تم النشر فى:
Journal of Medical Entomology
publications

Aedes aegypti (Culicidae), the mosquito that causes yellow fever, is regarded as a significant vector for
many disease agents. The current study sought to learn more about mosquito mid-gut…

بواسطة Sumaiah Al-Ghamdi, Mohamed A. Farrag, Rewaida Abdel-Gaber, Albandary Alrajeh, Saeed El-Ashram, Ommer Dafalla, Guillermo Tellez-Isaias, Mohammed Alkuriji , Reem Alajmi.
2023