تجاوز إلى المحتوى الرئيسي
User Image

Sara T Al-Rashood

Associate Professor

أستاذ مشارك

كلية الصيدلة
مكتب رقم 76الدورالثاني كليه الصيدله مبنى 8 - المدينه الجامعية للطالبات
المنشورات
مقال فى مجلة
2018

Synthesis, antimicrobial, anti-biofilm evaluation, and molecular modelling study of new chalcone linked amines derivatives, Journal of Enzyme Inhibition and Medicinal Chemistry

Ghada, Shahenda M. El-Messery, El-Sayed E. Habib, Sarah T. A. Al-Rashood & . 2018

A series of amide chalcones conjugated with different secondary amines were synthesised and characterised by different spectroscopic techniques 1H NMR, 13C NMR, and ESI-MS. They were screened for in vitro antibacterial activity. Compounds 36373842, and 44 are the most active among the synthesised series exhibiting MIC value of 2.0–10.0 µg/ml against different bacterial strains. Compound 36 was equipotent to the standard drug Ampicillin displaying MBC value of 2.0 µg/ml against the bacterial strain Staphylococcus aureus. The products were screened for anti-biofilm activity. Compounds 3637, and 38 exhibited promising anti-biofilm activity with IC50 value ranges from 2.4 to 8.6 µg. Molecular modelling was performed suggesting parameters of signalling anti-biofilm mechanism. AspB327 HisB340 (arene–arene interaction) and IleB328 amino acid residues seemed of higher importance to inhibit c-di-GMP. Hydrophobicity may be crucial for activity. ADME calculations suggested that compounds 3637, and 38 could be used as good orally absorbed anti-biofilm agents.

Keywords: Chalcones linked aminesantimicrobial/anti-biofilm activityc-di-GMP inhibitionmolecular modelling

 

رقم المجلد
33
رقم الانشاء
1
مجلة/صحيفة
Journal of Enzyme Inhibition and Medicinal Chemistry
الصفحات
818-832
مزيد من المنشورات
publications

Cancer stem cells (CSCs) have been objects of intensive study since their identification in 1994.

بواسطة Ghada H. Al-Ansary, Wagdy M. Eldehna, Hazem A. Ghabbour, Sara T. A. AlRashood,
2017
publications

A series of amide chalcones conjugated with different secondary amines were synthesised and characterised by different spectroscopic techniques 1H NMR, 13C NMR, and ESI-MS. They were screened for…

بواسطة Shahenda M. El-Messery, El-Sayed E. Habib, Sarah T. A. Al-Rashood & Ghada
2018
publications

مرادفات الثياديازولودايزبين - طرق تحضيرها - تركيباتها و فاعليتها كعلاج مبتكر لمرض الصرع

2017