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Dr.Siddique Akber Ansari

Associate Professor

Associate Professor

كلية الصيدلة
Department of Pharmaceutical Chemistry, College of Pharmacy building 23, King Saud University, P.O. Box 2457, Riyadh 11451,Saudi Arabia
المنشورات
مقال فى مجلة

Synthesis and Biological Activity of Structurally Diverse Phthalazine derivatives: A Systematic Review

Phthalazine, a structurally and pharmacologically versatile nitrogen-containing heterocycle, has gained more attention from medicinal chemists in the design and synthesis of novel drugs owing to its pharmacological potential. In particular, phthalazine scaffold appeared as a pharmacophoric feature numerous drugs exhibiting pharmacological activities, in particular, antidiabetic, anticancer, antihypertensive, antithrombotic, anti-inflammatory, analgesic, antidepressant and antimicrobial activities. This review presents a summary of updated and detailed information on phthalazine as illustrated in both patented and non-patented literature. The reported literature have described the optimal pharmacological characteristics of phthalazine derivatives and highlighted the applicability of phthalazine, as potent scaffold in drug discovery.

رقم المجلد
27
رقم الانشاء
18
الصفحات
3979-3997
مزيد من المنشورات
publications

Phthalazine, a structurally and pharmacologically versatile nitrogen-containing heterocycle, has gained more attention from medicinal chemists in the design and synthesis of novel drugs owing to…

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