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Prof. Dr. Shagufta Perveen FRSC-UK, PhD

Professor

Professor

كلية الصيدلة
Room # 57, 3rd Floor, Buil. # 8, Dept. of Pharmacognosy
المنشورات
مقال فى مجلة
2019

Montbresides A–D: Antibacterial p-coumaroyl esters of a new sucrose-based tetrasaccharide from Crocosmia × crocosmiiflora (montbretia) flowers

C.Fry, Author links open overlay panelShaguftaPerveenaIan H.SadlerbRahaOrfaliaAreej MohammadAl-TaweelaLornaMurraybStephen . 2019

Full length research paper

Crocosmia × crocosmiiflora (montbretia) flowers yielded four esters (montbresides A–D) of a new sucrose-based tetrasaccharide, 3-O-β-d-glucopyranosyl-4´-O-α-d-rhamnopyranosyl-sucrose [β-d-Glc-(1 → 3)-α-d-Glc-(1↔2)-β-d-Fru-(4 ← 1)-α-d-Rha]. All four possess O-p-coumaroyl residues on C-3 of fructose and C-4 of α-glucose, plus O-acetyl residues on C-2 and C-3 of rhamnose and C-6 of fructose. Montbresides A and B are additionally O-acetylated on C-1 of fructose. The p-coumaroyls are trans- in montbresides A and C and cis- in B and D. Elemental compositions were determined from MS data, and structures from 1D and 2D NMR spectra. Monosaccharide residues were identified from selective 1D TOCSY spectra and TLC, and acylation sites from 2D HMBC spectra. Enantiomers were distinguished by enzymic digestion. Montbretia flower extracts were cytotoxic against six human cancerous cell-lines, but purified montbresides lacked cytotoxicity. Each montbreside displayed antibacterial activity against Staphylococcus aureus (minimal inhibitory concentration ~6 μg/ml). Montbretia is a potential source of new cytotoxins and antibacterial agents.

نوع عمل المنشور
Fitoterapia, Elsevier
مجلة/صحيفة
https://doi.org/10.1016/j.fitote.2019.104377
الصفحات
1-8
مزيد من المنشورات
publications

Anvillea garcinii is a medicinal plant traditionally used for the treatment of dysentery, gastrointestinal troubles, hepatitis, lung disease, colds, digestive problems and pulmonary…

بواسطة Shagufta PerveenEmail authorAreej Mohammad Al-TaweelHasan Soliman YusufogluGhada Ahmed FawzyAhmed FoudahMaged Saad Abdel-Kader
2017
publications
بواسطة Author links open overlay panelAreej MohammadAl‑TaweelaMohammadRaishbShaguftaPerveenaGhada AhmedFawzyacAjazAhmaddMushtaq AhmadAnsarieShahidMudassargMajid AhmadGanaie
2017
publications

Anvillea garcinii is a medicinal plant used in the Arab region for intestinal diseases, lungs and liver diseases, digestive problems, and as an anti-diabetic. Repeated chromatographic…

بواسطة Shagufta Perveena,⁎ , Jawaher Alqahtania,d , Raha Orfalia , Areej Mohammad Al-Taweela , Hasan Soliman Yusufoglub , Maged Saad Abdel-Kaderb,c , Orazio Taglialatela-Scafati
2019