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Prof. Dr. Shagufta Perveen FRSC-UK, PhD

Professor

Professor

كلية الصيدلة
Room # 57, 3rd Floor, Buil. # 8, Dept. of Pharmacognosy
المنشورات
مقال فى مجلة
2017

Hepatoprotective and cytotoxic activities of Anvillea garcinii and isolation of four new secondary metabolites

Abdel-Kader, Shagufta PerveenEmail authorAreej Mohammad Al-TaweelHasan Soliman YusufogluGhada Ahmed FawzyAhmed FoudahMaged Saad . 2017

Full length research paper

Anvillea garcinii is a medicinal plant traditionally used for the treatment of dysentery, gastrointestinal troubles, hepatitis, lung disease, colds, digestive problems and pulmonary affections and in liver diseases. Four new sesquiterpene lactones, garcinamines A–D, along with seven known compounds, were isolated from the leaves of A. garcinii. This is the first report of the isolation of amino acid analogues of parthenolide-type sesquiterpene lactones from the family Asteraceae. Total ethanol extract of leaves as well as the chloroform and n-butanol fractions were tested for their hepatoprotective effect using the carbon tetrachloride liver toxicity model. The chloroform fraction, at a dose of 400 mg/kg, demonstrated a significant hepatoprotective effect comparable to silymarin in all serum and tissue parameters. The cytotoxicity of all extracts and compounds were evaluated against five human cancer cell lines: MCF-7, HCT-116, HepG2, Hela and A-549. The results indicated that the chloroform and n-butanol fractions and compounds 3, 4, 7 and 8 displayed significant cytotoxic activity against these cell lines.

نوع عمل المنشور
Journal of Natural Medicines, Springer
مزيد من المنشورات
publications

Anvillea garcinii is a medicinal plant traditionally used for the treatment of dysentery, gastrointestinal troubles, hepatitis, lung disease, colds, digestive problems and pulmonary…

بواسطة Shagufta PerveenEmail authorAreej Mohammad Al-TaweelHasan Soliman YusufogluGhada Ahmed FawzyAhmed FoudahMaged Saad Abdel-Kader
2017
publications
بواسطة Author links open overlay panelAreej MohammadAl‑TaweelaMohammadRaishbShaguftaPerveenaGhada AhmedFawzyacAjazAhmaddMushtaq AhmadAnsarieShahidMudassargMajid AhmadGanaie
2017
publications

Anvillea garcinii is a medicinal plant used in the Arab region for intestinal diseases, lungs and liver diseases, digestive problems, and as an anti-diabetic. Repeated chromatographic…

بواسطة Shagufta Perveena,⁎ , Jawaher Alqahtania,d , Raha Orfalia , Areej Mohammad Al-Taweela , Hasan Soliman Yusufoglub , Maged Saad Abdel-Kaderb,c , Orazio Taglialatela-Scafati
2019