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Shaik Sarfaraz Nawaz

Researcher

Researcher

كلية الطب
Strategic Center for Diabetes Research, College of Medicine, King Saud University
المنشورات
مقال فى مجلة
2019

Potential role of serum fetuin-A in relation with pro-inflammatory, chemokine and adhesion molecules in diabetic kidney disease: a case–control study.

, Shaik Sarfaraz Nawaz, Salini Scaria Joy, Yousuf Al Farsi, Teena P. George, Khalid Siddiqui. . 2019

Inflammatory cytokine, adipokine and adhesion molecules are known to play a key role in pathogenesis of diabetic kidney disease (DKD). In this study, our aim was to investigate the role of fetuin-A in relation with pro-inflammatory cytokines (IL-6, IL-18), adipokines (adiponectin, leptin), chemokine (MCP-1), and adhesion molecules (ICAM-1, VCAM-1) in control and DKD subjects. We recruited a total of 224 type 2 diabetic (T2D) subjects. The control subjects were T2D with a normal albumin excrete (albumin-to-creatinine ratio—ACR ≤ 30 mg/g creatinine) and estimated glomerular filtration rate (eGFR) ≥ 60 (ml/min/1.73 m2), while cases were T2D subjects with albumin excrete (ACR ≥ 30 mg/g creatinine) and eGFR ≤ 60 (ml/min/1.73 m2). FBS, HbA1c, lipid profile (TC, LDL, HDL, triglyceride), ALT, AST, GGT, serum creatinine, BMI, blood pressure was evaluated in all the study subjects. Randox evidence biochip analyzer was used for measuring inflammatory cytokines, adipokines, and adhesion molecules by chemiluminescent assay. Serum fetuin-A and IL-18 were measured by ELISA kits. Serum fetuin-A levels were significantly decreased in DKD cases compare to control group [456.8 (299.2–649.0) µg/ml versus 670.6 (573.0–726.1) µg/ml; p < 0.001)]. Serum fetuin-A levels correlates significantly with IL-6, IL-18, TNF-α, PAI-1, leptin, resistin and ACR (p < 0.001). This study concludes that serum fetuin-A and pro-inflammatory markers (IL-18, IL-6, IL-1α and TNF-α) might play an important role in the pathophysiology and inflammatory process of DKD.

نوع عمل المنشور
Original Research
رقم المجلد
46
مجلة/صحيفة
Molecular Biology Reports
الصفحات
1239–1246
مزيد من المنشورات
publications

Abstract

بواسطة K Siddiqui, TP George, SS Joy, SS Nawaz,
2020
تم النشر فى:
The Journal of Maternal-Fetal & Neonatal Medicine
publications

Metabolomics is rapidly evolving omics technology in personalized medicine, it offers a new avenue for identification of multiple novel metabolic mediators of impaired glucose tolerance and…

بواسطة S Chowdhury, SM Faheem, SS Nawaz, K Siddiqui,
2021
تم النشر فى:
Personalized Medicine