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Shaik Sarfaraz Nawaz

Researcher

Researcher

كلية الطب
Strategic Center for Diabetes Research, College of Medicine, King Saud University
المنشورات
مقال فى مجلة
2019

Significance of glycated LDL in different stages of diabetic nephropathy

, Khalid Siddiqui, Teena P George, Shaik Sarfaraz Nawaz, Maram Yaslam, Ebtehal Almogbel, Khalid Al-Rubeaan. . 2019

Aim:The aim of this study was to investigate the role of elevated glycated LDL (low-density lipoprotein) in the progression of diabetic kidney disease among type 2 diabetes (T2D) subjects. Materials and methods: This case-control observational study is a part of Saudi Diabetes KidneyDisease (SAUDI-DKD) study conducted during the period from April 2014 to June 2015. This study cohort is divided into two groups; the first group was T2D patients without diabetic nephropathy (DN) (n = 24) and the second group was T2D with DN (n = 45). Serum glycated LDL levels were determined by ELISA. Pearson's correlation analysis was performed, and the diagnostic accuracy was assessed using the area under the ROC curve. Results:There was a threefold increase of serum glycated LDL level among diabetic subjects when compared with non-diabetic subjects and this level progressively increased with the progression of DN. The glycated LDL was found to have a significant diagnostic accuracy with AUC of 0.685 and 0.775 for cases with microalbuminuria and macroalbuminuriarespectively. Conclusion: The glycated LDL could play a significant role in predicting diabetic patients who are susceptible to develop DN among T2D patients.

نوع عمل المنشور
Original Research
رقم المجلد
13
مجلة/صحيفة
Diabetes & Metabolic Syndrome: Clinical Research & Reviews
الصفحات
548-552
مزيد من المنشورات
publications

Abstract

بواسطة K Siddiqui, TP George, SS Joy, SS Nawaz,
2020
تم النشر فى:
The Journal of Maternal-Fetal & Neonatal Medicine
publications

Metabolomics is rapidly evolving omics technology in personalized medicine, it offers a new avenue for identification of multiple novel metabolic mediators of impaired glucose tolerance and…

بواسطة S Chowdhury, SM Faheem, SS Nawaz, K Siddiqui,
2021
تم النشر فى:
Personalized Medicine