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سليمان يوسف عبدالرحمن العمر

Associate Professor

أستاذ مشارك علم مناعة الاورام

كلية العلوم
مبنى 4 / مبنى 5: AB104
المنشورات
مقال فى مجلة
2015

The Relationship between Killer Cell Immunoglobulin-Like Receptors and HLA-C Polymorphisms in Colorectal Cancer in a Saudi Population.

, 27. Al Omar SY, Mansour L, Dar JA, Alwasel S, Alkhuriji A, Arafah M, Al Obeed O, Christmas S. . 2015

AIMS:

We performed an association study to evaluate the contribution of 16 killer cell immunoglobulin-like receptor (KIR) genotype polymorphisms and the HLA-C1 and -C2 ligands in the development of colorectal cancer (CRC) in Saudi Arabian patients.

METHODS:

A total of 52 patients with different stages of malignant CRC as well as 70 healthy Saudi controls were enrolled at the King Khalid University Hospital.

RESULTS:

Our results showed that the frequency of the activating mutations KIR2DS1, 2DS2, 2DS3, 2DS5, and 3DS1 was significantly higher in CRC patients compared to controls. The 3DS1 gene contributed to the highest risk of CRC (odds ratio [OR] = 16.25, p < 0.0001), followed by 2DS1 (OR = 8.6; p < 0.0001). The distributions of HLA-C1 and -C2 ligands were not significantly different between patients and controls. Analyses of different combinations of KIR genes with their HLA-C1 and -C2 ligands show that the frequency of 2DL3 in the presence of its ligand, the allotype C1, was significantly more prevalent in patients compared to controls. In addition, 2DL2 and 2DL3 that were aggregated in combination with the ligand, HLA-C1, were found to be more highly associated mainly with the homozygote HLA-C1/C1 (p = 0.03; OR = 2.6). The activating mutations 2DS1 and 2DS2 when combined with their respective ligands, HLA-C2 and -C1, showed highly significant associations with CRC development.

CONCLUSION:

This study supports a key role for KIR gene mutations in the development of CRC, especially in association with their ligands.

نوع عمل المنشور
بحث
رقم المجلد
11
رقم الانشاء
19
مجلة/صحيفة
Genetic testing and molecular biomarkers
الصفحات
617-622.
مزيد من المنشورات
publications

Frequencies of natural killer (NK) cells from patients with non-small cell lung cancer (NSCLC) or small cell lung cancer (SCLC) did not differ from healthy controls.

بواسطة 50. Al Omar, S. Y., Marshall, E., Middleton, D., & Christmas, S. E.
2011
publications

CD56+ T cells were studied in samples of peripheral blood from small-cell lung cancer (SCLC) and non-small-cell lung cancer (NSCLC) patients compared with healthy controls.

بواسطة 48. Al Omar, S. Y., Marshall, E., Middleton, D., & Christmas, S. E.
2012
publications

These experiments were designed to investigate the effects of IL-17 upon the phenotype and function of human Natural Killer (NK) cells.

بواسطة . Al Omar S, Flanagan BF, Almehmadi M, Christmas SE
2013