A study on chronic effect of profenofos on acetylcholinesterase and butyrylcholinesterase activities and protein contents in various tissues in major corps.

Journal Article
, Ghazala Ghazala, Shahid Mahboob, K. A. Al-Ghanim, Salma Sultana, Tayyaba Sultana, F. Al- Misned, L. Ahmed, Tehniat Shahid and Z. Ahmad . 2016
Publication Work Type: 
Research Article
Magazine \ Newspaper: 
Afr. J. Tradit. Complement Altern. Med.,
Issue Number: 
Volume Number: 
Publication Abstract: 

Pesticides widely used for agricultural purposes are carbamates, organophosphates as well as organochlorines. Among these pesticides, organochlorine compounds have been extensively used to control disease vectors as well as agricultural pests. The objective of this experiment was to study the chronic effect of a commercial formulation of profenofos on acetylcholinesterase (AChE) and butylcholinesterase (BuChE) activity in various tissues in Catla catla, Labeo rohita and Cirrhinus mrigala fingerlings was investigated.
T”he least activity of AChE was recorded in muscle samples of Catla catla (1.07±0.040 μmoles/min/g of protein), exposed to the highest concentration of profenofos. BuChE activity was also reduced against various concentrations of profenofos. The AChE and BuChE activity was significantly inhibited even when exposed to a minimum concentration of this insecticide. Profenofos exposure affected the functioning of brain, blood, gills, muscle, kidneys and liver”. We concluded that profenofos caused more inhibition in the liver for AChE and BuChE compared to other tissues.