تجاوز إلى المحتوى الرئيسي
User Image

أفراح فهد عبدالله الخريجي

Professor

أستاذ علم وظائف الاعضاء وبيولوجية التكوين

كلية العلوم
مبنى 5 الدور الثالث مكتب 112
المنشورات
مقال فى مجلة
2019

Lack of association between IL10 and TNFα gene polymorphisms and polycystic ovary syndrome in Saudi women

Alnafjan1, A.F. Alkhuriji1 , S.Y. Al Omar1 , Z.A. Babay2 , M.F. El-khadragy1,3 , W.G. Allharbi1 and A.A. . 2019

ABSTRACT. Polycystic ovarian syndrome (PCOS) is the most prevalent endocrine disorder affecting females. It is a common cause of menstrual irregularities and infertility during a woman’s reproductive years. Many factors may play a crucial role in the pathogenesis of POCS. One of these factors is related to immunogenetics. Cytokines are significant immunomodulatory proteins for regulating and controlling cell functions involved in the immune system. The imbalance between pro- and anti-inflammatory pathways plays a role in PCOS etiology. We investigated the relationship between gene polymorphisms interleukin (IL-10) (rs1800871, rs1800872, rs1800896) and tumor necrosis (TNF-α) (rs1799724) in Saudi women with PCOS .The study group consisted of 93 Saudi females (mean age 31.05 ± 0.590, range 18–40 years) with PCOS. The control group consisted of 98 Saudi women without PCOS. Blood was obtained, and DNA was extracted for each patient and control. Single nucleotide polymorphisms (SNPs) of promoter regions were determined using Taq Man genotyping assays the polymorphism frequencies in IL-10 (rs1800871) A/A, A/G, and G/G genotypes were 7.5%, 38.7%, and 53.76%, respectively in PCOS patients and 5.1%, 45.9%, and 49.0%, respectively in controls with no significant differences between the groups. No significant differences in IL-10 polymorphism frequencies in C/C, C/T, and T/T between groups were noted. No significant differences were seen sample parameters for TNF between groups with respect to the TNFα. The differences in frequencies of alleles and genotypes were not significant between Saudi women with PCOS and controls. We conclude that though in some populations, meta-analyses showed an association between IL-10 and TNF-α gene polymorphisms and PCOS, this association is not apparent in Saudi females.

رقم المجلد
18
رقم الانشاء
3
مجلة/صحيفة
Genet. Mol. Res.
الصفحات
1-9
مزيد من المنشورات
publications

Hepatitis C virus remained a public health problem with approximately half of the patients untreated and
undiagnosed. Chronic HCV is a leading cause of cirrhosis, fibrosis, hepatocellular…

بواسطة Mahnoor a, Mamoona Noreen a,⇑, Muhammad Imran b, Sher Zaman Safi c, Muhammad Amjad Bashir d, Afrah Fahad Alkhuriji e, Suliman Yousef Alomar e, Hanan Mualla Alharbi e
2021
publications

Abstract: Methylenetetrahydrofolate reductase (MTHFR) deficiency is the most common genetic cause of
hyperhomocysteinemia, which has been implicated in the etiology of recurrent spontaneous…

بواسطة AFRAH ALKHURIJI1; ATEKAH ABDULLAH MOHAMMED ALRAQIBAH1; AMAAL AWAD ALHARBI1; ZENEB BABAY2; FATIMAH BASIL AL-MUKAYNIZI3; ARWA ALTHOMALI3; SONYA S. ABDEL-RAZEQ4; ARJUMAND S. WARSY5
2020
publications

study, the protective potential of chlorogenic acid (CGA), a caffeoylquinic acid isomer abundantly found in many
plants, was investigated against sodium arsenite (NaAsO2)-induced testicular…

بواسطة Manal F. El-Khadragy a,b,*, Wafa A. AL-Megrin a, Suliman Alomar c, Afrah F. Alkhuriji d, Dina M. Metwally d,e, Shahenda Mahgoub f, Hatem K. Amin f, Ola A. Habotta g, Ahmed E. Abdel Moneim b, Rasha S. Albeltagy
2021