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احمد علي احمد علام

Assistant Professor

أستاذ مساعد

كلية العلوم
King Saud University, College of Science, Department of Zoology, Riyadh11451, Saudi Arabia
المنشورات
مقال فى مجلة
2016

Effect of parsley (Petroselinum crispum, Apiaceae) juice against cadmium neurotoxicity in albino mice (Mus musculus).

ZY7., Maodaa SN1, Allam AA2,3, Ajarem J4, Abdel-Maksoud MA5, Al-Basher GI6, Wang . 2016

BACKGROUND:

Parsley was employed as an experimental probe to prevent the behavioral, biochemical and morphological changes in the brain tissue of the albino mice following chronic cadmium (Cd) administration.

METHODS:

Non-anesthetized adult male mice were given parsley juice (Petroselinum crispum, Apiaceae) daily by gastric intubation at doses of 10 and 20 g/kg/day. The animals were divided into six groups: Group A, mice were exposed to saline; Groups B and C, were given low and high doses of parsley juice, respectively; Group D, mice were exposed to Cd; Groups E and F, were exposed to Cd and concomitantly given low and high doses of parsley, respectively.

RESULTS:

Cd intoxication can cause behavioral abnormalities, biochemical and histopathological disturbances in treated mice. Parsley juice has significantly improved the Cd-associated behavioral changes, reduced the elevation of lipid peroxidation and normalized the Cd effect on reduced glutathione and peroxidase activities in the brain of treated mice. Histological data have supported these foundations whereas Cd treatment has induced neuronal degeneration, chromatolysis and pyknosis in the cerebrum, cerebellum and medulla oblongata.

CONCLUSION:

The low dose (5 g/kg/day) of parsley exhibited beneficial effects in reducing the deleterious changes associated with Cd treatment on the behavior, neurotransmitters level, oxidative stress and brain neurons of the Cd-treated mice.

نوع عمل المنشور
paper
مزيد من المنشورات
publications

Nicotine exposure during pregnancy induces oxidative stress and leads to behavioral alterations in early childhood and young adulthood. The current study aimed to investigate the possible…

بواسطة 1) Jamaan S. Ajarem, Gadh Al-Basher, Ahmed A. Allam and Ayman M. Mahmoud
2017
publications

In the present study, it was hypothesized that micromorphology of the surface of many lizard scales appears to mimic the topography of the habitat in which they live. Many authors have suggested…

بواسطة 5) Allam AA, Abo-Eleneen R, ALOthman S.
2017
publications

The power of tumorigenesis, chemo-resistance and metastasis in malignant ovarian
tumors resides in a tiny population of cancer cells known as ovarian cancer stem cells (OCSCs).

بواسطة Amoura Abou-ElNaga, Ghada Mutawa, Ibrahim M. El-Sherbiny, Hassan Abd-ElGhaffar, Ahmed A. Allam, Jamaan Ajarem and Shaker A. Mousa
2017