GENO PROTECTIVE AND ANTI-APOPTOTIC EFFECT OF GREEN TEA AGAINST PERINATAL LIPOPOLYSACCHARIDE-EXPOSURE INDUCED LIVER TOXICITY IN RAT NEWBORNS
Chow, Ahmed A. Allam, Sami A. Gabr , Jamaan Ajarem, Ahmad H. Alghadir, Revathi Sekar and Billy KC . 2017
Background: This study aims to examine the protective effect of green tea on the disturbances in oxidative stress and
apoptosis related factors, mostly produced due to perinatal lipopolysaccharide (LPS) exposure, that subsequently
induces liver cell damage.
Materials and Methods: Anti-free radical, Antioxidant, scavenging, geno-protective, and antiapoptotic activity of
aqueous green tea extract (AGTE) were assessed against LPS-induced hepatic dysfunction in newborn-rats. AGTE at
doses of 100 & 200 mg/kg was orally administered daily to rat dams, during gestation and lactation.
Results: AGTE was observed to exhibit protective effects by significantly attenuating LPS-induced alterations in
serum AST, ALT, bilirubin, and albumin levels. Significant increase in the total antioxidant capacity (TAC), DNA
contents, and reduction in nitric oxide (NO) levels were observed in AGTE treated rats comparing LPS-toxicated ones.
Additionally, AGTE treatment significantly down-regulated apoptotic markers and this effect was directly correlated to
the degree of hepatic fibrosis. The possible mechanisms of the potential therapeutic-liver protective effect of AGTE
could be due to free radical scavenging potential and antiapoptotic properties caused by the presence of antioxidant
polyphenolic components in AGTE.
Conclusion: We thereby propose, based on our findings, that the anti-free radical and anti-apoptotic inducing
properties of AGTE active constituents attribute to its functional efficacy as anti-fibrotic agent.
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