Camellia sinensis prevents perinatal nicotine-induced neurobehavioral alterations, tissue injury and oxidative stress in male and female mice newborns

Journal Article
Mahmoud, 1) Jamaan S. Ajarem, Gadh Al-Basher, Ahmed A. Allam and Ayman M. . 2017
Publication Work Type: 
paper
Magazine \ Newspaper: 
Oxidative Medicine and Cellular Longevity (Impact factor: 4.42)
Issue Number: 
[Epub ahead of print]
Volume Number: 
[Epub ahead of print]
Pages: 
[Epub ahead of print]
Publication Abstract: 

Nicotine exposure during pregnancy induces oxidative stress and leads to behavioral alterations in early childhood and young adulthood. The current study aimed to investigate the possible protective effects of green tea (Camellia sinensis) against perinatal nicotine-induced behavioral alterations and oxidative stress in mice newborns. Pregnant mice received 50 mg/kg C. sinensis on gestational day 1 (PD1) to postnatal day 15 (D15) and were subcutaneously injected with 0.25 mg/kg nicotine from PD12 to D15. Nicotine-exposed newborns showed significant delay in eye opening and hair appearance, and declined body weight at birth and at D21. Nicotine induced neuromotor alterations in both male and female newborns evidenced by the suppressed righting, rotating and cliff avoidance reflexes. Nicotine-exposed newborns exhibited declined memory, learning and equilibrium capabilities, as well as marked anxiety behavior. C. sinensis significantly improved the physical development, neuromotor maturation and behavioral performance in nicotine-exposed male and female newborns. In addition, C. sinensis prevented nicotine-induced tissue injury and lipid peroxidation, and enhanced antioxidant defenses in the cerebellum and medulla oblongata of male and female newborns. In conclusion, this study shows that C. sinensis confers protective effects against perinatal nicotine-induced neurobehavioral alterations, tissue injury and oxidative stress in mice newborns. 

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